Publications by authors named "E M Shobe"
Three hundred and forty-two university students completed the Short Dark Triad (SD3) and the Edinburgh Handedness Inventory (EHI). Inconsistent handers showed higher psychopathy scores than consistent handers, and no handedness differences were observed for narcissism or Machiavellianism. Participants were further subdivided by quartile into low, moderately low, moderately high, and high psychopathy groups (non-clinical).
View Article and Find Full Text PDFIndependent and collaborative contributions of the cerebral hemispheres to emotional processing.
Front Hum Neurosci
June 2014
Article Synopsis
- The model suggests the right hemisphere (RH) is primarily responsible for recognizing and processing both positive and negative emotions, while the left hemisphere (LH) aids in higher-level emotional processing through connections established via the corpus callosum.
- Initial emotional processing occurs in the RH through its subcortical connections, which then relay information to the cortical structures, allowing the hemispheres to work together for a more comprehensive emotional understanding.
- The LH is less capable of recognizing negative emotions and tends to have a default positive bias, relying on the RH for emotional identification. Collaborative processing between both hemispheres is essential for a complete understanding of negative emotions.
We investigated the effects of increased inter-hemispheric interaction (IHI) on five creativity dimensions (appropriateness, detail, categorical distinctiveness, fluency, and originality) of the Alternate Uses Task. Two methods were used to indicate degree of IHI. Trait IHI was indicated by individual differences in handedness, mixed-handers showing greater IHI than strong-handers.
View Article and Find Full Text PDFPurpose: The purpose of this work was to evaluate an oral absorption prediction model, maximum absorbable dose (MAD), which predicts a theoretical dose of drug that could be absorbed across rat intestine based on consideration of intestinal permeability, solute solubility, intestinal volume, and residence time.
Methods: In the present study, Caco-2 cell permeability, as a surrogate for rat intestinal permeability, and aqueous solubility were measured for 27 oxazolidinones. The oxazolidinones are a novel class of potential antibacterial agents currently under investigation.
A rapid, accurate and precise HPLC-ESI-MS method for the determination of rat plasma uridine concentrations was developed and is described here. Sample preparation involves methanol precipitation of plasma proteins in a 96-well Captiva protein precipitation filter plate. A clear extract is drawn through the filter plate with vacuum, followed by evaporation of the extract and subsequent reconstitution prior to chromatography on a reversed-phase column with an aqueous mobile phase [0.
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