[Steroid balance in breast cancers of varying histological structure].

Patients with breast cancer in stage I--II of various histological structure showed varied hormonal disturbances. In adenocarcinoma a high level of classic estrogens or total phenolsteroids was noted. In low differentiated cancers (solid, scirrhus) the values of estrogens excretion were considerably lower, but, if correlated with other hormones (androsterone), a relative hyperestrogenization is observed.

[Immunologic reactivity of the body and the adrenal cortex function in the early period after administration of a carcinogen].

The level of immunological reactivity and the functional state of the adrenal cortex were studied simultaneously in BALB/c mice 7 days after a single injection of various doses of methylcholanthrene. There existed a definite correlation between the immunodepression induced by various doses of methylcholanthrene determined according to the amount of plaque-forming cells in the experimental mouse spleen and free and combined 11-corticosteroids content in the blood plasma after 7 days of the carcinogen injection. This evidence suggests that the adrenal cortex hormones play a definite role in the pathogenesis of immunodepression induced by chemical carcinogenesis.

[Steroid balance in patients with breast hyperplasia].

A correlation was found between the character of hormonal disorders and the morphological organization of dyshormonal hyperplasias of the mammary gland. Patients with fibroadenoma and fibrous-cystic mastopathy are characterized by a high diurnal urine content of glucocorticoids and low estrogens level, especially estradiol. Patients with cystic fibroadenomatosis of the mammary gland show the high level of the excretion of classical and total phenolsteroids and low androsterone level.