Sensitivity and resistance to antibiotics of Streptococcus pneumoniae involved in severe infections (1990-2000).

S. pneumoniae implicated in severe infections presents now a high frequency of the resistant strains to Penicillin G or multiresistance in the whole world. Our study on 136 strains of invasive pneumococcus isolated in the last 10 years showed a medium resistance to penicillin of 22.

[Actual considerations in pneumococcal meningitis].

Streptococcus pneumoniae has been recognized as a bacterial pathogen in human beings. It was the main cause of meningitis, almost since it was first isolated by Sternberg and Pasteur more than 100 years ago. Meningitis is constantly lethal without specifically treatment.

[A retrospective clinical study on pneumococcal meningitis in 0- to 1-year-old infants hospitalized in 1987-1996 in the Infectious Disease Clinic, Iaşi].

During a period of ten years (1987-1996) in Iaşi Infections Diseases Hospital, were observed 19 children, 0-1 year, with pneumococcal meningitis. This disease represented one important cause of morbidity and mortality in children in developing countries. Clinical symptoms in these cases were very serious, including: fever, headache, vomiting, altered sensorium, seizures etc.

The influence of plasma butyrylcholinesterase concentration on the in vitro hydrolysis of cocaine in human plasma.

In humans, the plasma enzyme butyrylcholinesterase, BChE (EC 3.1.1.

Pharmacokinetic evaluation of twice-daily extended-release carbamazepine (CBZ) and four-times-daily immediate-release CBZ in patients with epilepsy.

Purpose: A new capsule dosage form of carbamazepine (CBZ) has been developed, consisting of three different types of beads (immediate-release, extended-release, and enteric-release) that may be taken sprinkled on food or swallowed for easy administration. We compared the pharmacokinetics of the extended-release dosage form of CBZ (Carbatrol capsules) twice daily with the conventional immediate-release formulation of CBZ four times daily.

Methods: The randomized, double-blind, two-way, cross-over study was conducted at two sites, with a planned sample size of 24 adult patients with epilepsy.