Vancomycin-Associated Hemorrhagic Occlusive Retinal Vasculitis: A Clinical-Pathophysiological Analysis.

Purpose: To derive novel insights into the pathophysiology of vancomycin-related hemorrhagic occlusive retinal vasculopathy (HORV) through a careful clinicopathologic correlation.

Methods: We retrospectively reviewed the clinical and pathologic course of 2 consecutive patients who developed HORV. The clinical history, multimodal imaging, ultrasound biomicroscopy (UBM), and intraoperative and histologic findings are reported.

Noninvasive diagnosis of epithelial downgrowth after penetrating keratoplasty using immunohistochemical analysis of resected corneal buttons.

Purpose: To describe a noninvasive technique that can be used to support a clinically suspected diagnosis of epithelial downgrowth in patients who have previously undergone penetrating keratoplasty (PK).

Methods: Previously resected corneal buttons of 14 patients who developed signs suggestive of epithelial downgrowth after PK were examined retrospectively using immunohistochemical analysis to determine if occult epithelial cells were in fact present on the posterior surface of the cornea. Many of these patients were diagnosed with pseudophakic corneal edema or graft failure and had undergone multiple intraocular surgical procedures.

Autosomal dominant neovascular inflammatory vitreoretinopathy.

Twenty-eight of 61 members of a six-generation family are affected by an autosomal dominant eye disease which has not been described previously. Affected patients are asymptomatic in early adulthood, but have vitreous cells and the selective loss of the b-wave on the electroretinogram. Later, peripheral retinal scarring and pigmentation, peripheral arteriolar closure, and neovascularization of the peripheral retina at the ora serrata or occasionally neovascularization of the optic disc develop.