Publications by authors named "E M Ponomarchuk"
Objective: Non-invasive surgical approaches, including boiling histotripsy (BH), are currently being developed for the treatment of brain disorders aiming to avoid craniotomy and exposure of intervening tissues, and, thus, minimize associated complications. This work aimed to demonstrate the feasibility of BH for mechanical fractionation of human brain tissues ex vivo under B-mode guidance, with preliminary measurements of tissue stiffness via shear wave elastography.
Methods: Young's moduli of 25 human autopsy brain samples obtained from de-identified patients of 51-91 y old (median 77 y old) were measured via shear wave elastography prior to BH sonication.
Article Synopsis
- The study explores boiling histotripsy (BH) for non-invasive kidney tumor ablation, focusing on different BH dose metrics in porcine and canine kidney models.
- Various pulsing protocols were tested to assess lesion formation, revealing that in vivo kidney tissue required lower BH doses compared to ex vivo tissue for similar damage.
- Results indicated tissue stiffness and damage differed between kidney compartments, with the renal cortex needing fewer pulses for effective treatment, while the medulla and renal sinus showed higher resistance to BH dosing.
We present the results of a pilot study demonstrating the feasibility of non-invasive non-thermal disintegration of human mucinous carcinoma of the breast ex vivo using sequences of high-intensity focused ultrasound pulses in boiling histotripsy regimen. The target volume was sonicated by focusing ultrasound pulses (n=20) of 1.5 MHz frequency, 10-msec duration and 1-sec pulse repetition period, 517 W acoustic power within the pulse, and 103 MPa shock front amplitude at the focus into each node of a volumetric grid 4×4×1 mm.
View Article and Find Full Text PDFObjective: As an alternative to surgical excision and magnetic resonance-guided thermal high-intensity focused ultrasound ablation of uterine leiomyoma, this work was aimed at pilot feasibility demonstration of use of ultrasound-guided boiling histotripsy for non-invasive non-thermal fractionation of human uterine leiomyoma ex vivo.
Methods: A custom-made sector ultrasound transducer of 1.5-MHz operating frequency and nominal f-number F# = 0.
Objective: Tissue susceptibility to histotripsy disintegration has been reported to depend on its elastic properties. This work was aimed at investigation of histotripsy efficiency for liquefaction of human hematomas, depending on their stiffness and degree of retraction over time (0-10 d).
Methods: As an in vitro hematoma model, anticoagulated human blood samples (200 mL) were recalcified at different temperatures.