Publications by authors named "E M Nemoto"
Article Synopsis
- Sepsis is a severe condition marked by inflammation and blood vessel dysfunction, leading to high hospital mortality rates, and new methods are needed to combat it.
- Research has shown that using drag-reducing polymers (DRPs) can enhance blood flow and oxygen delivery in the body, providing protection to brain cells in traumatic situations.
- In experiments with mice, DRPs improved microcirculation and oxygen supply, reducing harmful effects of sepsis compared to a control group that only received saline, indicating their potential as a treatment strategy for sepsis-related complications.
Article Synopsis
- The study aimed to explore how eye tracking (ET) metrics relate to brain tissue oxygen levels in patients with moderate COVID-19 pneumonia.
- Conducted on 92 patients around 34 years old, it measured eye movement reactivity using mobile technology while assessing cerebral oxygenation through specialized equipment.
- Results showed a correlation between eye movement responses and oxygen saturation in the brain, indicating that oxygen levels significantly impact eye coordination during COVID-19 pneumonia.*
An early event in the pathology of traumatic brain injury (TBI) is a reduction in cerebral blood flow (CBF), which exacerbates secondary injury development and inhibits brain recovery. The endogenous cannabinoid system signalling (eCBs) might be critical in TBI recovery due to modulating synaptic activity and exerting neuroprotective and anti-inflammatory effects. In the brain, eCBs predominantly occur at cannabinoid receptor type 1 via the eCB 2-arachidonoylglycerol (2-AG).
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- The evaluation methods for assessing the injured brain have progressed significantly since 1960, when Lundberg first introduced intracranial pressure (ICP) measurement.
- Building on this, later research examined cerebral blood flow (CBF) and critical cerebral perfusion pressure (CPP) to better understand brain autoregulation and its limitations, particularly when mean arterial pressure (MAP) decreases.
- Recent advancements such as induced pressure reactivity (iPRx) and continuous multimodal monitoring have improved the identification of optimal CPP for patients with traumatic brain injury, but challenges remain regarding understanding the mechanisms behind CBF autoregulation loss due to increased ICP.
Article Synopsis
- The study aimed to evaluate the occurrence of posttraumatic cerebral ischaemia (PTCI) and monitor intracranial pressure (ICP) during the transportation of patients with severe traumatic brain injuries (TBI).
- It included 153 TBI patients, with findings showing that all displayed signs of PTCI, and that roughly 38% had ischaemia affecting both brain hemispheres.
- The results indicated that ICP significantly increased during transportation, particularly during vertical movement, with an average rise from 19.9 mm Hg to 26.1 mm Hg.