[Pulmonary tuberculosis in the indigenous population in the Republic of Tyva: clinical and social aspects].

The Republic of Tyva is a most poor tuberculosis region in the Russian Federation. The main epidemiological indices of this disease are 2.5-3 times greater than the average indices in Russia.

[The association of tuberculosis with the specificities of the HLA gene DRB1 in different regions of Tuva].

The fact that genetic factors largely determine susceptibility to different diseases, including those of infectious nature is beyond question now. Tuberculosis is not an exception in this respect. HLA genes that determine different immunological phenomena make a certain contribution to tuberculosis susceptibility.

[Incidence of tuberculosis in the areas of the Republic of Tyva].

The incidence of tuberculosis was analyzed in all 16 districts and Kyzyl (the capital) of the Republic of Tyva in 1998-2002. There was an increase in its incidence rates (from 13.15 to 133.

[Genotypic characteristics of Mycobacterium tuberculosis strains from the Republic of Tyva].

To determine the genetic heterogenicity of Mycobacterium tuberculosis isolated from patients with tuberculosis from different districts of the Republic of Tyva, 71 M. tuberculosis strains IS6110 according to the polymorphism of restriction fragment lengths were typed; of them 32 strains were spoligotyped. The study could genetically characterize the groups of M.

[Examining the distribution of HLA antigens in patients with tuberculosis and healthy individuals in some regions of the Republic of Tyva].

Healthy individuals and patients with pulmonary tuberculosis were typed by HLA antigens A, B, and C. They were all Tyvians and lived in different regions of the Republic of Tyva. Examination was made in 128 and 85 healthy individuals and 62 and 55 patients with pulmonary tuberculosis from the Todzhinsky and Erzinsky districts of the Republic of Tyva, respectively.