Publications by authors named "E M Martini"
Background: Heart failure (HF) is strongly associated with inflammation. In pressure overload (PO)-induced HF, cardiac stress triggers adaptive immunity, ablation or inhibition of which blocks disease progression. We hypothesized that PO-HF might fulfill the often-used criteria of autoimmunity: if so, the associated adaptive immune response would be not only necessary but also sufficient to induce HF; it should also be possible to identify self-antigens driving the autoimmune response.
View Article and Find Full Text PDFPharmacokinetic evaluation of fezolinetant for the treatment of vasomotor symptoms caused by menopause.
Expert Opin Drug Metab Toxicol
October 2024
Article Synopsis
- Vasomotor symptoms (VMS) affect many menopausal women and can negatively impact their quality of life, with available treatments like menopausal hormone therapy (MHT) posing risks for some.
- Fezolinetant is a newly approved oral non-hormonal drug that targets neurokinin 3 receptors to help alleviate moderate to severe VMS and has demonstrated effectiveness in clinical trials.
- The drug appears to improve VMS-related issues such as sleep and overall quality of life while maintaining a safe profile, highlighting its potential as a key option for women unable to use hormone therapy, although further research is needed.
Article Synopsis
- There is growing recognition that endometriosis can affect postmenopausal women, but there is still limited information available on its prevalence and clinical management in this demographic.
- Symptoms of endometriosis in menopausal patients can be vague and may appear at any stage, making accurate diagnosis challenging.
- Surgical excision remains the main treatment for symptomatic postmenopausal endometriosis, though there's ongoing debate about the use of hormone therapy due to potential risks, highlighting the need for more research in this area.
Emotional processing in binge drinking, tobacco use disorder and their comorbidity in youth: A preregistered PRISMA scoping review.
Prog Neuropsychopharmacol Biol Psychiatry
January 2025
Background: Binge drinking (BD) and tobacco use disorder (TUD) are prevalent among youth, with significant social and health implications. However, research into the emotional impairments associated with BD and TUD during adolescence is sparse and lacks integration within a comprehensive model of emotional processes. Moreover, the impact of comorbid BD and TUD on emotional deficits remains largely unexplored.
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