Publications by authors named "E M Macias"
Article Synopsis
- Kounis syndrome (KS), identified in 1991, is a rare condition involving allergic reactions that can lead to coronary spasms and heart issues.
- It results from allergens triggering mast cells, causing symptoms like angina and potentially life-threatening myocardial infarctions.
- While KS is uncommon, there's an even rarer occurrence of heart attacks from allergic reactions to gadolinium, with incidences as low as 0.002-0.01%.
The Centers for Disease Control and Prevention defines SARS-CoV-2 reinfection as a positive COVID-19 test result >90 days after the collection date for the initial positive test or if sequencing confirms a different lineage is causing the reinfection. Reinfection dynamics have been examined by using PCR or antigen surveillance data. We identified patients in the US Military Health System who had >1 positive SARS-CoV-2 test during March 2020-July 2022 by using whole-genome sequencing data to identify reinfection cases, then compared those data with patient demographics, symptoms, and vaccination status.
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- Peripancreatic adipose tissue (PAT), which accumulates with obesity, negatively affects metabolic health and beta cell function, highlighting its significance compared to subcutaneous adipose tissue (SAT).
- PAT secretes higher levels of inflammatory substances and certain adipokines linked to poor metabolic outcomes, with variations in islet insulin secretion observed between male and female donors.
- RNA sequencing reveals that PAT influences gene transcription and lipid metabolism in islets in a sex-dependent manner, suggesting different metabolic impacts compared to SAT.
Article Synopsis
- The study investigates the genetic factors linked to severe COVID-19, specifically focusing on hospitalized cases in admixed Americans.
- Researchers conducted the largest genome-wide association study (GWAS) for COVID-19 hospitalization in this population, identifying four significant genetic associations, including two novel loci found in Latin Americans.
- The findings highlight the importance of including diverse populations in genomic research, aiming to improve understanding of genetic risks associated with COVID-19 across different ethnic groups.
Background: Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy. In the last few years, after the publication of the consensus guidelines, with refined diagnostic criteria and improved awareness, FPIES is diagnosed with increased frequency. However, despite having a background of immune dysregulation, this complication has just been described once in the posttransplant setting, in an adult patient.
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