Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer.

Patients with metastatic pancreatic ductal adenocarcinoma survive longer if disease spreads to the lung but not the liver. Here we generated overlapping, multi-omic datasets to identify molecular and cellular features that distinguish patients whose disease develops liver metastasis (liver cohort) from those whose disease develops lung metastasis without liver metastases (lung cohort). Lung cohort patients survived longer than liver cohort patients, despite sharing the same tumor subtype.

Deaf adult insights into elements of classroom discourse altered in interpretation.

In this study, 19 college-educated deaf adults with experience using interpreters in educational settings provided insights into how successfully various elements of classroom discourse were preserved through interpretation. The deaf adults, fluent in American Sign Language (ASL) and experienced at using interpreters, watched educational interpreters' renditions of an elementary school art lesson, and answered questions, providing information about the clarity, completeness, and coherence of the message. Next, the deaf adults were asked to compare what they saw in the first interpretation of the lesson to what was conveyed in a second iteration by a highly experienced interpreter familiar with the lesson whose first language is ASL.

A high species diversity of (Basidiomycota, Hymenochaetales) in Central and South America, revealed after morphological and molecular analysis.

A study of corticioid fungi collections from Costa Rica, Panama, Colombia, and Ecuador has resulted in the identification of 26 morphospecies of . These distinctions were made based on characters such as basidiospore size and shape, cystidia morphology, basidioma texture, and hymenial surface configuration. Sequences of rDNA ITS were obtained for 12 of these species, and their relationships to previously known taxa were illustrated using Bayesian and Maximum Likelihood reconstructions of the phylogeny.

Uplifting local ecological knowledge as part of adaptation pathways to wildfire risk reduction: A case study in Montseny, Catalonia (Spain).

Living with wildfires in an era of climate change requires adaptation and weaving together many forms of knowledge. Empirical evidence of knowledge co-production in wildfire management is lacking in Mediterranean European areas. We explored how local ecological knowledge can be leveraged to reduce wildfire risk through an adaptation pathways process in the Montseny massif and wider Tordera River watershed of Catalonia, Spain: an area stewarded through forestry and agriculture, tourism, nature conservation, and fire management.