Publications by authors named "E M Krieger"
We investigated and compared mortality rates and risk factors for pre-pandemic and pandemic all-cause mortality in a population-based cohort of men and women in Arkhangelsk, Russia. A prospective cohort study enrolled 2,324 participants aged 35 to 69 years between 2015 and 2017. All participants were followed up for all-cause deaths using the mortality registry.
View Article and Find Full Text PDFBackground: Patients with systemic right ventricle (SRV), either d-transposition of the great arteries following an atrial switch procedure or congenitally corrected transposition of the great arteries, develop severe right ventricular dysfunction, prompting appropriate medical therapy. However, the efficacy of beta-blockers and angiotensin receptor blockers or angiotensin-converting enzyme inhibitors (ACEI) in SRV patients is unproven.
Objectives: The objective of this study was to determine the effects of ACEI/ARB and beta-blockers on outcomes in SRV patients after accounting for likely cofounders affecting their use.
Article Synopsis
- - Patients with repaired tetralogy of Fallot are prone to ventricular tachycardia and sudden cardiac death, with most arrhythmias linked to specific slow-conducting areas in the heart known as SCAIs.
- - The study compared a "prophylactic" approach, which involved ablating SCAIs regardless of whether VT was induced, to a "historical" approach that used VT induction to guide treatment, focusing on reducing complications and the need for implantable cardioverter-defibrillators (ICDs).
- - Results showed that patients who underwent prophylactic ablation had no major arrhythmic events over a median follow-up of 21 months, whereas 29% of the historical group
Article Synopsis
- A Phase II clinical trial examined the effects of intravenous vitamin C on patients receiving hematopoietic stem cell transplants to reduce nonrelapse mortality (NRM).
- Patients (55 total) were given IV vitamin C for 14 days, which corrected their initial vitamin C deficiency and showed a trend towards lower NRM (11%) compared to historical controls (25%).
- The study suggests that vitamin C repletion is safe and may improve survival rates (82% vs. 62%), but further randomized trials are necessary to validate these findings.
Article Synopsis
- * A survey involving 1,089 unvaccinated participants revealed that 59.7% had experienced COVID-19, with 47.1% of those exhibiting symptoms and 8.6% hospitalized, while 96.2% of asymptomatic cases were not reported.
- * Findings indicate a link between older age and poor self-rated health with increased COVID-19 severity and hospitalization, emphasizing the need for better surveillance to detect asymptomatic infections.