Publications by authors named "E M Koomen"

Article Synopsis
  • The CRUCIAL trial is studying the impact of allopurinol on brain injury in newborns with critical congenital heart disease (CCHD) undergoing heart surgery.
  • The aim is to understand how the drug is metabolized (pharmacokinetics) during different surgical phases and to see if current dosing achieves effective drug levels.
  • Results showed a complex drug absorption model with a 100% target attainment for allopurinol levels immediately after birth, but varying success rates during the surgical process, indicating adjustments may be needed in administration timing or dosage.
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Combatting land damage has become a global priority, and China has adopted a series of ecological engineering measures, especially in the agro-pastoral area with fragile ecological environment. The effectiveness of ecological engineering construction (EEC), from a comprehensive recognition encompassing its quality, quantity, and function, has remained largely unknown. To this end, Zhangbei County, a typical agro-pastoral ecotone of northern China, was chosen as our focal area.

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Article Synopsis
  • The study aimed to see if using intermittent intravenous paracetamol instead of continuous morphine would help kids aged 0-3 years feel less pain after heart surgery.
  • It took place in special hospitals in the Netherlands and Belgium, and involved 208 children who had heart surgery, where they were split into two groups to compare pain relief methods.
  • The results showed that kids who received paracetamol used much less morphine (79% less) for pain relief in the first 48 hours after surgery than those who got only morphine.
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Urban densification is a key strategy to accommodate rapid urban population growth, but emerging evidence suggests serious risks of urban densification for individuals' mental health. To better understand the complex pathways from urban densification to mental health, we integrated interdisciplinary expert knowledge in a causal loop diagram via group model building techniques. Six subsystems were identified: five subsystems describing mechanisms on how changes in the urban system caused by urban densification may impact mental health, and one showing how changes in mental health may alter urban densification.

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