Impact of Hospital Volume on Survival for Pediatric Wilms Tumor.

Background: Treatment for children with Wilms tumor (WT) is multidisciplinary, often including surgery, chemotherapy, and sometimes radiation therapy. High-volume hospitals (HVH) have been associated with improved outcomes in cancer care. Our study evaluates the association of hospital volume and survival outcomes in pediatric WT management.

Opinion research among Russian Physicians on the application of technologies using artificial intelligence in the field of medicine and health care.

Background: To date, no opinion surveys has been conducted among Russian physicians to study their awareness about artificial intelligence. With a survey, we aimed to evaluate the attitudes of stakeholders to the usage of technologies employing AI in the field of medicine and healthcare and identify challenges and perspectives to introducing AI.

Methods: We conducted a 12-question online survey using Google Forms.

Approaches to prediction of the adaptive state of the brain energetic system under conditions of hypoxia.

We showed that mitochondrial creatine kinase activity can be predicted from the ATP level and that changes in ATP content can be evaluated by activity of mitochondrial creatine kinase under experimental conditions.

[Dependence between mitochondrial creatine kinase activity and ATP level in the brain ischemia].

The disturbances of blood circulation changes metabolism and energy reactions in the brain. The method of mathematical analysis is used for the study of the dependence between the activity mitochondrial creatine kinase (CK) and ATP level the brains of rats subjected to acute and chronic ischemia. A model describing this dependence under different conditions of the activity of organisms has been proposed.

[Properties of NAD-dependent brain enzymes under the conditions of hypoxia and ischemia].

The catalytic properties of mitochondrial and cytoplasmic isoenzymes of NAD-dependent brain malate dehydrogenase (MDH) were studied under hypoxic or ischemic conditions. Hypoxia was modeled in animals in pressure chamber, while ischemia was achieved via bilateral ligation of common carotic arteries. The properties of MDH in mitochondria of rat brain were studied; they were significantly different from those of MDH purified from bovine brain.