Applying Osteosarcoma Immunology to Understand Disease Progression and Assess Immunotherapeutic Response.

Osteosarcoma, the most common malignant bone tumor in children and adolescents, remains a complicated disease to treat; no new treatments have been developed in more than three decades. Due to the importance of the immune system in osteosarcoma disease progression, immunotherapeutic strategies have been explored to potentially improve long-term survival. However, most immunotherapeutics have not reached the level of success hoped would occur in this disease.

[Sexual dysfunction in treated hypertensive patients. Results of a national survey].

Objectives: To evaluate, using an self-administered questionnaire, the characteristics of sexual function in treated hypertensives.

Methods: In 459 hypertensive subjects, aged of 59 +/- 12 years, living in France and referred to hypertension specialists, a self-administered questionnaire evaluating quality of life and antihypertensive treatment was given before the consultation. Several questions focused on the quality of sexual function since the last 12 months (interest for sexuality, sexual pleasure, quality of erection).