[Parathyreoidectomy in Rats Using Microsurgery and Medical Adhesive Sulfacrylate].

Background: One of the main difficulties in assessing the effectiveness of etiologic treatment of hypoparathyroidism is absence of its standardized model.

Objective: The aim of the study was to develop a method of hypoparathyroidism modeling.

Methods: Controlled nonrandomized study was performed on female Wistar rats aged 10 month.

Development of laboratory rats receiving silver-enriched ration for a long time.

We studied the effect of silver ions on the status and metabolism of copper in rats receiving Ag-diet from the first day of life and for 6 months. The effect of silver ions on copper metabolism was assessed by body weight, relative weight of organs (body weight/organ weight), oxidase activity, content of immunoreactive ceruloplasmin and copper concentration in blood serum, by the expression of copper-transporting protein genes in the liver, and copper and silver distribution in liver and brain cells. Brain functions were evaluated by open-field behavior and passive avoidance conditioning.

[Quality of life of patients before and after surgical treatment of diffuse toxic goiter].

Quality of life of 89 patients with diffuse toxic goiter was analyzed before surgical intervention and at different terms after thyroidectomy or terminal subtotal resection of the thyroid gland using questionnaire SF-36. It was found that quality of life of patients with diffuse toxic goiter was lower than that of respondents without such pathology. The indices of quality of life one year after thyroidectomy (terminal subtotal resection of the thyroid gland) remained depending on the duration of the disease and complications of thyrotoxicosis, became reliably larger as compared with preoperative level due to social activity and emotional state.

[Specific features of laryngeal paresis following surgical treatment of diffuse toxic goiter (a prospective longitudinal passive study)].

Specific manifestations of postoperative laryngeal paresis observed with the use of indirect laryngoscopy are described in 53 patients subjected to the surgical treatment of diffuse toxic goiter. Laryngeal paresis was shown to develop both in the early (up to 7 days) and in the late (over 14 days) postoperative periods. The delayed form of pathology accounted for 13% of the total number of the cases of postoperative laryngeal paresis.

[Characteristics of rat ceruloplasmin from the serum of animals, which received salts of silver with food].

Abiogenic Ag(I) ions have electronic structure, similar to Cu(I) ions and can compete with Cu(I) for binding sites of proteins which transport copper from extracellular media to sites of cuproenzyme formation in the cell. Rodents receiving Ag-salts with food develop extracellular deficiency of copper associated with ceruloplasmin (Cp, the major copper-transporting protein in blood serum of vertebrates). The present work focuses on the studies of biochemical and physicochemical properties of Cp, obtained from blood serum of rats, which received AgCl with food for 4 weeks (Ag-rats).