Transient exposure to ketamine can trigger lasting changes in behavior and mood. We found that brief ketamine exposure causes long-term suppression of futility-induced passivity in larval zebrafish, reversing the "giving-up" response that normally occurs when swimming fails to cause forward movement. Whole-brain imaging revealed that ketamine hyperactivates the norepinephrine-astroglia circuit responsible for passivity.
View Article and Find Full Text PDFPediatric liver transplant outcomes exhibit disparities, necessitating identification of modifiable risk factors to develop targeted interventions. We characterized associations between household material economic hardship (e.g.
View Article and Find Full Text PDFBackground: Overt immune activation by viral infections can lead to cytokine storm syndromes, such as hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS).
Objective: We aim to compare the immune response to different viral pathogens to understand the connection between infections and cytokine storm syndromes.
Methods: We recruited children who presented to the emergency room with fever for ≥ 3 days.
Background: Structural remodeling has been associated with increased incidence of atrial fibrillation, but how fibrotic regions allow atrial fibrillation to be sustained remains unclear.
Objective: With a novel transgenic goat model, we evaluated structural and functional differences between structurally remodeled and healthy regions of the atria.
Methods: A novel transgenic goat model with cardiac-specific overexpression of transforming growth factor β1 was used.