The clinical and molecular landscape of diffuse hemispheric glioma, H3 G34-mutant.

Background: Diffuse hemispheric glioma, histone 3 (H3) G34-mutant, has been newly defined in the 2021 WHO classification of central nervous system tumors. Here we sought to define the prognostic roles of clinical, neuroimaging, pathological, and molecular features of these tumors.

Methods: We retrospectively assembled a cohort of 114 patients (median age 22 years) with diffuse hemispheric glioma, H3 G34-mutant, CNS WHO grade 4 and profiled the imaging, histological and molecular landscape of their tumors.

A conserved switch to less catalytically active Polycomb repressive complexes in non-dividing cells.

Polycomb repressive complex 2 (PRC2), composed of the core subunits EED, SUZ12, and either EZH1 or EZH2, is critical for maintaining cellular identity in multicellular organisms. PRC2 deposits H3K27me3, which is thought to recruit the canonical form of PRC1 (cPRC1) to promote gene repression. Here, we show that EZH1-PRC2 and cPRC1 are the primary Polycomb complexes on target genes in non-dividing, quiescent cells.

Evaluating the transition of adolescents and young adults with palliative care needs from pediatric to adult care.

Background: The transition from pediatric to adult healthcare poses significant challenges for adolescents and young adults (AYA), especially those with chronic conditions, yet most children receive inadequate transition preparation. Research on the transition for patients receiving palliative care services is particularly limited. We sought to address this gap in the literature.

An ideal compressed mask for increasing speech intelligibility without sacrificing environmental sound recognitiona).

Hearing impairment is often characterized by poor speech-in-noise recognition. State-of-the-art laboratory-based noise-reduction technology can eliminate background sounds from a corrupted speech signal and improve intelligibility, but it can also hinder environmental sound recognition (ESR), which is essential for personal independence and safety. This paper presents a time-frequency mask, the ideal compressed mask (ICM), that aims to provide listeners with improved speech intelligibility without substantially reducing ESR.