Publications by authors named "E M Harmon"
The experience of tinnitus can range from inducing annoyance to debility. In the US, tinnitus is estimated to affect 1 in 10 adults, though it is known to be underreported. Often dismissed, tinnitus can be a precursor for treatable pathologies.
View Article and Find Full Text PDFStructures of Trichomonas vaginalis macrophage migratory inhibitory factor.
Acta Crystallogr F Struct Biol Commun
December 2024
Article Synopsis
- Trichomonas vaginalis is a one-celled parasite that causes trichomoniasis, the most common nonviral STD worldwide, and it uses mimicry of human proteins to evade the immune system.
- The parasite produces a protein called TvMIF, which helps it survive stress, boosts prostate cell growth, and triggers inflammation, paralleling the effects of human MIF.
- Recent studies have revealed the structure of TvMIF, showing it has a similar shape to human versions, suggesting that understanding this protein can aid in developing new drugs.
Crystal structure of N-terminally hexahistidine-tagged Onchocerca volvulus macrophage migration inhibitory factor-1.
Acta Crystallogr F Struct Biol Commun
December 2024
Article Synopsis
- Onchocerca volvulus is responsible for serious health issues, including blindness and neurological diseases, and current treatments like ivermectin can't be safely used in pregnant women or those co-infected with Loa loa.
- Researchers at the Seattle Structural Genomics Center for Infectious Disease have successfully produced and crystallized a potential drug target called OvMIF-1, which has a unique jellyfish-like structure.
- The study suggests that deleting its N-terminal tag could reveal a larger cavity for drug targeting, indicating the need for further analysis to confirm the true biological structure of OvMIF-1.
Background: The 2019 coronavirus (COVID-19) outbreak was declared a global pandemic in March 2020. It quickly spread across all continents, causing significant social, environmental, health, and economic impacts. During the pandemic, there has been consideration of repurposing and repositioning of medications, such as corticosteroids, for the treatment of hospitalised COVID-19 patients.
View Article and Find Full Text PDFThe Hemodynamic Effects of Interatrial Septostomy in Iatrogenic Mitral Stenosis Following MitraClip.
J Soc Cardiovasc Angiogr Interv
July 2024
Article Synopsis
- - Iatrogenic mitral stenosis is an uncommon complication that can occur after the MitraClip procedure, with few treatment options available.
- - The text discusses a specific case where real-time echocardiographic and hemodynamic data were used to explore a new treatment approach.
- - It suggests that creating an interatrial septostomy could be a potential percutaneous management option for patients facing this complicated condition.