Development of a self-management tool for individuals with seizure clusters: Trial design and methodological report.

Background: Despite advances in anti-seizure medications (ASMs) for people with epilepsy (PWE), adverse outcomes, negative health events (NHEs), and breakthrough seizures remain common. Rescue medication (RM) can better manage repetitive seizures, but barriers to RM use persist. Self-management for PWE and a history of NHEs (SMART) is an evidence-based epilepsy self-management program aimed at reducing barriers and maximizing facilitators to self-care in high-risk PWE.

Acute Placental Inflammation Is Associated with Reduced Progesterone Receptor Density in the Basal Decidua in Spontaneous Preterm Birth.

Objective:  A functional progesterone withdrawal has been thought to contribute to the pathophysiology of spontaneous preterm birth (PTB). The density of the progesterone receptor (PR) in gestational tissues could play a role in functional progesterone withdrawal. We sought to understand the relationship between placental pathology and the density of PR in the basal decidua in the setting of spontaneous preterm delivery.

Heteroresistance associated with the production of fosfomycin-resistant inner colonies during disk diffusion testing among a geographically diverse collection of clinical isolates.

Background: Fosfomycin susceptibility breakpoints apply only to despite clinical use against EUCAST and CLSI have different breakpoints and guidelines for disk diffusion (DD) interpretation that are frequently extrapolated to Guidelines differ in interpreting inner colonies (IC) that grow within the zone of inhibition, but specificity to leaves knowledge gaps when extrapolating to other uropathogens.

Objectives: To examine the frequency and MIC of IC during fosfomycin DD testing and to determine potential relationships between IC production, heteroresistance and presence.

Methods: A collection of clinical isolates ( = 262) and their IC ( = 116) underwent broth microdilution testing.

Disseminated infection in a Belgian Malinois.

We report disseminated mycosis in a Belgian Malinois caused by . The dog presented for progressive hindlimb weakness after diagnosis of suspected bacterial discospondylitis. Magnetic resonance imaging combined with radiographs revealed multifocal discospondylitis, osteomyelitis, and spondylitis with epidural empyema.

Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure.

Background: PDE2 (phosphodiesterase 2) is upregulated in human heart failure. Cardiac PDE2-transgenic mice are protected against contractile dysfunction and arrhythmias in heart failure but whether an acute elevation of PDE2 could be of therapeutic value remains elusive. This hypothesis was tested using cardiac PDE2 gene transfer in preclinical models of heart failure.