Publications by authors named "E M Gutina"
Short linear peptide fragments of placental trophoblastic β1-glycoprotein (PSG) (YECE, YQCE, YVCS, and YACS) were studied in the context of their immunomodulatory effects at the level of inflammatory markers. The original host-versus-graft model was used in male Wistar rats without prior conditioning of recipient bone marrow. A composition of PSG peptide fragments was injected to animals after allogeneic transplantation of bone marrow cells in a dynamic experiment, inflammatory markers α1-acid glycoprotein (AGP, orosomucoid), α2-macroglobulin (α2M) were assayed by ELISA, and biochemical parameters (total protein, glucose, creatinine, and urea) were measured.
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- Benz(a)pyrene administration at 20 mg/kg significantly increased the excretion of lysosomal enzymes in rat bile without harming the lysosomes.
- Constant exposure to light altered liver cell function, enhancing lysosomal activity while suppressing regular bile enzyme release.
- When benz(a)pyrene treatment was combined with light exposure, it reduced the stimulatory effects on lysosomal enzyme transport to bile but didn't completely remove the impact.