APPLICATION OF QUERCETIN FOR CORRECTION OF THE IMPAIRMENT OF THE FUNCTIONAL STATE OF THE ENDOTHELIUS OF VESSELS (CLINICAL AND EXPERIMENTAL STUDY).

Objective: in the experiment, to investigate the effect of Quercetin on the NO-dependent reactions of isolated vessels involving endothelium and perivascular adipose tissue (PVAT) after a single X-ray irradiation of rats at a sublethal dose. In a clinical study, to investigate the effect of long-term use of Quercetin on the functional state of themicrovascular endothelium in the elderly patients with metabolic syndrome (MS).

Material And Methods: Experimental studies were performed on vascular fragments obtained from adult male rats(7-8 months) of the control group, in animals exposed to a single R-irradiation at a dose of 7 Gy and animals irradiated in the same dose, which received Quercetin orally for 14 days three times a week based on 10 mg/kg bodyweight.

[THE CLINICAL SIGNIFICANCE OF ENDOSCOPIC MANOMETROGRAPHY OF UPPER GASTROINTESTINAL TRACT IN PATIENTS WITH CHRONIC PANCREATITIS].

The Purpose Of The Research: To study the cavitary esophagogastroduodenal pressure in patients with chronic pancreatitis (CP) depending on the dominant clinical symptoms--gastroesophageal reflux (GER) and abdominal pancreatic pain.

Material And Methods: By esophagogastroduodenoscopy that included manometrography and acid-perfusion test--were examined 86 patients with CP and 25 healthy individuals.

Results: 63% of patients with CP detected changes of the esophagus and the lower esophageal sphincter (LES) based on the endoscopy, or manometrography, or test with 0.

[Effect of Korargin on reactivity of isolation aorta of adult and old irradiated rats].

Introduction to the diet of adult (7-8 months) and old (24-26 months) male rats for 30 days after a single R-irradiation at a dose of 5 Gy of preparation "Korargin" (whose active ingredients are L-arginine, contributing to the prevention of endothelial dysfunction, and inosine) in old irradiated rats significantly increased the relaxation of isolated segments of thoracic aorta by the action of acetylcholine, sodium nitroprusside and insulin. In adults irradiated animals this effect was not observed. Vasoconstriction response of isolated segments of thoracic aorta to norepinephrine was decreased in isolated segments of thoracic aorta by adults and old irradiated rats compared with controls, and application of korargin had no significant effect.

[Effect of preparation "Korargin" on metabolic syndrome manifestations in adult and old rats exposed to x-ray irradiation].

Introduction to the diet of adult and old rats for 30 days after R-irradiation at a dose of 5 Gy drug "Korargin" prevented the development of some manifestations of radioinduced metabolic syndrome (MS) in animals of both age groups: in adult irradiated animals--a tendency to decrease insulin levels in blood plasma, increase of cholesterol levels in liver tissue, significantly increased serum high density lipoprotein as compared both to controls and irradiated animals, prevented the decrease in the levels of anions NO2- and NO3- in tissue of the aorta and anions NO2- in tissue of the heart; in old irradiated animals--prevented tended to increase of body weight, the increase in insulinresistance (index HOMA), the decrease in the level of anions NO2- in the aorta tissue, increased levels of anions NO2- and NO3- in the heart tissue compared to controls. Prevention through drug "Korargin" some manifestations of radioinduced MS in adult and old animals, indicates the prospects of exploring the possibility of correction of the violations of carbohydrate and lipid metabolism caused by exposure to ionizing radiation, in individuals of both age groups.

[Biomechanical rationale of the tense screw-pin osteosynthesis of proximal humerus fractures].

This article developed the question of biomechanical studies of new low-impact method of surgical treatment of fractures of the proximal humerus. Designed latch consists of standard needles with a diameter 2 mm cortical screws with diameter 4.5 mm and fixing washers original design.