Publications by authors named "E M Flachs"
Objectives: Previous studies have indicated that maternal occupational psychosocial stressors may affect the risk of asthma in the offspring, but their results are inconsistent. Maternal occupational ergonomic strain is associated with predictors of fetal lung development, including preterm birth and low birthweight; however, it is not known, whether ergonomic strain during pregnancy is a risk factor for asthma in offspring. The aim was to investigate maternal psychosocial stressors and ergonomic strain during pregnancy relative to the risk of offspring asthma.
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- This study investigates the link between wet work conditions and moderate-to-very-severe hand eczema (HE) using a job exposure matrix (JEM) in the Dutch general population.
- With data from the Lifelines Cohort Study, researchers found significant connections between various wet work factors and HE, particularly in female participants.
- The findings highlight the need for further observational research to clarify these associations, especially considering the limitations of the JEM approach.
Article Synopsis
- A Job Exposure Matrix (JEM) was developed to evaluate occupational hand-wrist exposures linked to job titles and hand-wrist disorders in Denmark, covering 96 job groups.
- The JEM was validated through expert ratings and showed fair to good inter-rater reliability while revealing that carpal tunnel syndrome (CTS) risk increased with greater levels of force, repetition, and vibration.
- The study concluded that the JEM effectively identifies risk factors for CTS and provides insights into exposure-response relationships and interactions between different types of work-related exposures.
Article Synopsis
- Preeclampsia may lead to poor remodeling of placental spiral arteries, which, combined with abnormal angiogenesis and excessive complement activation, contributes to recurrent pregnancy loss (RPL).
- The study examines angiogenic factors and lectin complement pathways in early pregnancies of 76 women with secondary RPL and finds that certain biomarkers, like elevated VEGF levels, are linked to pregnancy loss.
- Results indicate that inadequate placentation and impaired angiogenesis may underlie pregnancy losses in women experiencing secondary RPL, with a notable association between ficolin-2 levels and pregnancy outcomes, while Mannose-binding-lectin showed no significant correlation.