Publications by authors named "E M Elli"
Calreticulin (CALR) mutations are detected in around 20% of patients with primary and post-essential thrombocythemia myelofibrosis (MF). Regardless of driver mutations, patients with splenomegaly and symptoms are generally treated with JAK2-inhibitors, most commonly ruxolitinib. Recently, new therapies specifically targeting the CALR mutant clone have entered clinical investigation.
View Article and Find Full Text PDFSurgical management of candy cane syndrome after Roux-en-Y bypass.
Surg Obes Relat Dis
November 2024
Background: Candy cane (CC) syndrome is a complication that occurs following Roux-en-Y bypass (RYGB), implicated as a long, small-bowel blind limb at gastrojejunostomy possibly caused using circular staplers.
Objectives: We aimed to report our experience with CC resection and improving outcomes following RYGB.
Setting: University hospital.
Incretin-based obesity management medications (OMMs) fill a treatment gap in a stepped-care model between lifestyle change alone and metabolic bariatric surgery, resulting in weight loss of 15% to 20% of body weight. Public interest in and demand for OMMs has recently increased dramatically. Unfortunately, cost and access to OMMs remain a significant barrier for many patients.
View Article and Find Full Text PDFArticle Synopsis
- Myeloproliferative neoplasms are disorders involving stem cells, where chronic inflammation plays a significant role in complications like blood clots, and the neutrophil-to-lymphocyte ratio (NLR) is becoming a potential prognostic tool for assessing these conditions.
- A study of 473 patients with essential thrombocythemia showed that a high NLR at diagnosis (≥4) increased the risk of both arterial and venous thrombotic events, alongside other factors such as diabetes and hypertension.
- The NLR is an accessible inflammatory marker that could be used alongside traditional cardiovascular risk assessments to identify patients at higher risk for thrombosis in essential thrombocythemia.
Nissen fundoplication (NF) is a common surgical procedure to treat gastroesophageal reflux disease; however, a subset of patients may continue to experience symptoms or develop symptom recurrence despite a successful procedure. This study aims to compare laparoscopic and robotic approaches for treating failed NF and evaluate the outcomes after converting to Toupet fundoplication (TF). We conducted a retrospective analysis of patients who underwent robotic or laparoscopic revision to TF for failed NF between 2016 and 2023.
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