Publications by authors named "E M De Leenheer"

Introduction: A vestibular deficit can have a substantial impact on the overall development of children. Therefore, it is of utmost importance that vestibular-impaired problems are treated early and effectively through Vestibular Rehabilitation Therapy (VRT). Although VRT is sufficiently proven and standardised in adults, there remains a lack of research examining its efficacy in children.

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CHARGE syndrome, characterized by a distinct set of clinical features, has been linked primarily to mutations in the gene. Initially defined by specific clinical criteria, including coloboma, heart defects, choanal atresia, delayed growth, and ear anomalies, CHARGE syndrome's diagnostic spectrum has broadened since the identification of . Variants in this gene exhibit considerable phenotypic variability, leading to the adoption of the term " disorder" to encompass a wider range of associated symptoms.

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Importance: Congenital cytomegalovirus (cCMV) is the major cause of congenital nonhereditary sensorineural hearing loss in children. Currently, criteria to identify infants at increased risk for unfavorable hearing outcome are lacking.

Objective: To identify risk factors associated with cCMV-related hearing improvement, hearing deterioration, and late-onset hearing loss.

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Background: Congenital cytomegalovirus infection (cCMV) is the most common congenital infection worldwide and is a major cause of neurodevelopmental impairment in children. At this point there are insufficient data on neurodevelopmental outcome of children with cCMV, both symptomatic and asymptomatic.

Aim: This study aimed to describe the neurodevelopmental outcome in a large prospective cohort of children with cCMV.

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Article Synopsis
  • Congenital cytomegalovirus (cCMV) is a major cause of hearing loss in children and can also affect balance, but there's a lack of consistent follow-up for vestibular issues in clinical settings.* -
  • This study included 185 cCMV patients, monitored using various vestibular tests at different ages, revealing that 16.8% experienced vestibular loss at some point during the follow-up period.* -
  • Most patients with vestibular impairment showed damage in both semicircular and otolith systems, indicating significant balance issues, regardless of whether they received antiviral treatment.*
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