Complex Genetic Framework in Familial Amyotrophic Lateral Sclerosis With a C9ORF72 Mutation: A Case Report.

A significantly diverse clinical presentation of amyotrophic lateral sclerosis (ALS), even in its best-studied familial form, continues to hinder current efforts to develop effective disease-modifying drugs for the cure of this rapidly progressive, fatal neuromuscular disease. We have previously shown that clinical heterogeneity of sporadic ALS (sALS) could be explained, at least in part, by its polygenic nature as well as by the presence of mutated genes linked to non-ALS neurological diseases and genes known to mediate ALS-related pathologies. We hypothesized that a similar genetic framework could also be present in patients with familial ALS (fALS).

Galveston Bay and Coastal Ocean Optical-Geochemical Response to Hurricane Harvey From VIIRS Ocean Color.

Dissolved and particulate organic carbon, suspended particulate matter concentrations, and their optical proxies colored dissolved organic matter absorption and backscattering coefficients were studied in Galveston Bay, Texas, following the extreme flooding of Houston and surrounding areas due to Hurricane Harvey (25-29 August 2017) using field and ocean color observations. A three-step empirical-semianalytic algorithm for determination of colored dissolved organic matter absorption and backscattering coefficients revealed the dynamics of dissolved organic carbon and particle distribution from Visible and Infrared Imaging Radiometric Suite ocean color. Environmental drivers, especially floodwater discharge and winds, strongly influenced the spatiotemporal distribution of dissolved/particulate material in the bay and shelf waters following the hurricane passage.

Changing Dynamics of Dissolved Organic Matter Fluorescence in the Northern Gulf of Mexico Following the Deepwater Horizon Oil Spill.

The characteristics of fluorescent components of dissolved organic matter (DOM) were examined using excitation emission matrix (EEM) fluorescence spectroscopy combined with parallel-factor analysis (PARAFAC) for seawater samples obtained from the northern Gulf of Mexico (NGoM) before, during, and after the 2010 Deepwater Horizon (DwH) oil spill. An EEMs PARAFAC modeling of samples collected within 16 km of the wellhead during the oil spill in May 2010, which included one typical subsurface sample with a PAH concentration of 1.09 μg/L, identified two humic-like and two previously reported oil-like components.

Prevention of bacterial foodborne disease using nanobiotechnology.

Foodborne disease is an important source of expense, morbidity, and mortality for society. Detection and control constitute significant components of the overall management of foodborne bacterial pathogens, and this review focuses on the use of nanosized biological entities and molecules to achieve these goals. There is an emphasis on the use of organisms called bacteriophages (phages: viruses that infect bacteria), which are increasingly being used in pathogen detection and biocontrol applications.

A semi-analytical total suspended sediment retrieval model in turbid coastal waters: a case study in Changjiang River Estuary.

A simple semi-analytical model to estimate total suspended sediment matter (3S) was established for estimating TSM concentrations in Changjiang River Estuary. The results indicate that 3S model with near-infrared wavelengths provide good estimates of TSM concentrations in the study region. Furthermore, the applicability of 3S model was evaluated using an independent data set taken from Oujiang river estuary during September 2012.