Publications by authors named "E M D'Angelo"

According to histopathology and molecular genetics, there are 5 major subtypes of ovarian carcinomas: high-grade serous (70%), endometrioid (10%), clear cell (10%), mucinous (3% to 4%), and low-grade serous (<5%) carcinomas. These tumors, which constitute over 95% of cases, represent distinct diseases with different prognoses and therapy. This review outlines contemporary advances in molecular pathology, which have expanded our knowledge of the biology of epithelial ovarian cancer and are also important to patient management.

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Article Synopsis
  • Macrophages play a crucial role in the immune response within the tumor environment of colorectal cancer (CRC), and their unique properties can be harnessed to create targeted nanoparticles for treatment.
  • Lipid nanovesicles (LNVs) were developed using membrane proteins from differentiated THP-1 cells, resulting in two types: T-LNVs and M1-LNVs, both loaded with the cancer drug doxorubicin (DOXO).
  • M1-LNVs demonstrated greater effectiveness in targeting and killing cancer cells compared to T-LNVs, showing promise for precision medicine in cancer therapy with reduced side effects.
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Introduction: The introduction of multiparametric prostate magnetic resonance imaging (mpMRI) has revolutionized prostate cancer (PCa) diagnosis, enhancing the localization of clinically significant prostate cancer (csPCa) and guiding targeted biopsies. However, significant disparities in the execution, interpretation, and reporting of prostate MRI examinations across centers necessitate greater standardization and accuracy. This study compares the diagnostic efficacy of mpMRI from academic and nonacademic centers in detecting csPCa and identifies factors associated with csPCa detection.

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Singleton pregnancy in Fontan patients is burdened by a significant maternal cardiovascular and obstetric risk. The cardiac workload in a twin pregnancy is greater and could place Fontan-palliated patients at an increased risk of complications. We report a case of a woman with Fontan circulation and homozygous mutation who had a twin pregnancy.

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