Baclofen prevents morphine rewarding effects and associated biochemical alterations in male and female mice.

Previous studies from our laboratory have shown sex differences in the behavioral, molecular, and neurochemical manifestations of morphine withdrawal and they were related to an increased sensitivity to morphine effects in males. In addition, we observed an interaction between the GABAergic and opioid systems that could also be sex-dependent. Baclofen, a GABA receptor agonist, prevented the somatic expression and the molecular and neurochemical changes induced by morphine withdrawal syndrome in mice.

GABA receptors blockage modulates somatic and aversive manifestations induced by nicotine withdrawal.

There is substantial evidence that GABA agonist, baclofen, prevents somatic and motivational responses induced by nicotine withdrawal and may target drug cue vulnerabilities in humans. In this context, we explored different aspects associated with the possible mechanisms whereby the GABA receptors might influence nicotine withdrawal. Male mice received nicotine (2.

New evidence on an old question: is the "fight or flight" stage present in the cardiac and respiratory regulation of decapod crustaceans?

The ability to stay alert to subtle changes in the environment and to freeze, fight or flight in the presence of predators requires integrating sensory information as well as triggering motor output to target tissues, both of which are associated with the autonomic nervous system. These reactions, which are commonly related to vertebrates, are the fundamental physiological responses that allow an animal to survive danger. The circulatory activity in vertebrates changes in opposite phases.

[Readmissions in a pilot psychiatric ward].

We did this work because the observation shows us a high percentage of readmissions in Psychiatric Services. Alejandro Korn Hospital has 2,306 beds, 98% of them occupied. Of these beds, 104 belong to neurology and 63 to clinic and surgery.

[Activity of a new neuroleptic, penfluridol (R-16341) in long-term treatments].

The difficulties of regular drug intake in long term treatments for psychotic patients gave rise to the need of using medicines at the longest possible intervals, facilitating thus adequate control and regularity. Penfluridol is a neuroleptic meeting that requirement: it is necessary only one dose per week. This paper reviews the results of Penfluridol in 26 patients (20 inpatients and 6 outpatients), ages between 17 and 54 with a mean of 36.