Publications by authors named "E M Baricheva"
Background: Understanding genome organization and evolution is important for species involved in transmission of human diseases, such as mosquitoes. Anophelinae and Culicinae subfamilies of mosquitoes show striking differences in genome sizes, sex chromosome arrangements, behavior, and ability to transmit pathogens. However, the genomic basis of these differences is not fully understood.
View Article and Find Full Text PDFThe Drosophila GAGA-factor encoded by the Trithorax-like (Trl) gene is DNA-binding protein with unusually wide range of applications in diverse cell contexts. In Drosophila spermatogenesis, reduced GAGA expression caused by Trl mutations induces mass autophagy leading to germ cell death. In this work, we investigated the contribution of mitochondrial abnormalities to autophagic germ cell death in Trl gene mutants.
View Article and Find Full Text PDFArticle Synopsis
- Detailed study of phylogeography is crucial for managing mosquito species that spread diseases like malaria, particularly focusing on the two related species, Anopheles messeae and An. daciae.
- The research used ribosomal DNA analysis and karyotyping across 28 Eurasian locations to uncover genetic diversity and population structure, highlighting significant differences in their chromosomes and indicating limited gene flow between the species.
- Findings suggest that An. messeae has a more complex genetic makeup than An. daciae, with implications for understanding malaria transmission risk in various regions, particularly in northern Europe.
Article Synopsis
- The study focuses on the phylogenetic relationships of malaria-carrying mosquitoes in the Maculipennis Group, examining how their traits and evolutionary history affect disease transmission.
- Phylogenomic analysis of 13 mosquito species revealed that the Palearctic species An. beklemishevi clusters with Eurasian species and showed closer ties to An. freeborni from North America than to An. quadrimaculatus.
- Migration patterns suggest that these mosquitoes moved from North America to Eurasia around 20-25 million years ago, with significant genetic exchanges occurring between isolated species, impacting their traits and adaptations.
Article Synopsis
- GAGA (GAF) is a transcription factor crucial for regulating gene expression during fly development, and its underexpression in mutants leads to significant germline cell death and reduced testis size.
- Our RNA-seq analysis identified 2,437 differentially expressed genes in GAGA underexpressed testes, revealing downregulation of normal testis genes and an increase in stress-related genes.
- The study concludes that GAGA deficiency causes metabolic imbalances and impaired mitochondrial function, contributing to cellular stress and sperm cell death, but no specific GAGA-dependent cell death pathway was identified.