Lower extremity revascularization based on intraoperative arteriography.

The traditional approach to patients with lower extremity ischemia involves "diagnostic" arteriography performed in a radiology angiography suite prior to a separate revascularization in an operating room suite. This time-honored and staged approach has the disadvantage of an associated significant angiographic complication rate. Furthermore, in view of the accuracy of noninvasive testing and the capacity for intraoperative arteriography, this separation of diagnostic and reparative techniques may be outdated and cost-ineffective.

Pharmacokinetics and metabolism of HOE 077. Preclinical studies.

The studies were performed in healthy male rats and in one male dog after oral and intravenous administration of [2-carbamoyl-14C]HOE 077. HOE 077 wa rapidly and completely absorbed after oral administration. In blood, tmax was at about 0.

Angiotensin II restoration of reflex adrenal medullary secretion to anephric dogs is physiologically dose dependent.

Acute nephrectomy seriously impairs hypovolemic adrenal epinephrine (E) release in the anesthetized dog. That systemically delivered angiotensin II totally restores E release to acutely anephric dogs is equally clear, but the dose-response relationship of this angiotensin II effect is not known. Adrenal secretion rates and arterial plasma E, norepinephrine (NE), and dopamine levels were studied in nine groups of mongrel dogs (n = 5 in each group) under pentobarbital anesthesia: 1) resting animals; 2) hemorrhage (25 ml/kg); 3) hemorrhage after acute nephrectomy; 4-7) hemorrhage, acute nephrectomy, plus iv angiotensin II at a) 0.

Renal modulation of electrically stimulated adrenal medullary secretion.

In acutely anephric dogs, depressed reflex adrenal medullary secretion (AMS) may be related to low plasma angiotensin. Either local (adrenal medulla) or central nervous system mechanisms are responsible. Local influences of acute bilateral nephrectomy on AMS were evaluated after left splanchnic nerve section.