The study aims to improve the ocular delivery of Nebivolol HCL (NBV) belonging to the Biopharmaceutics classification system (BCSII) by using spanlastic nanovesicles (SNVs) for ophthalmic delivery and incorporating them into hydroxypropyl methylcellulose gel with ketorolac tromethamine (KET) as an anti-inflammatory to improve glaucoma complications like Conjunctivitis. SNVs were prepared by ethanol injection technique using span (60) as a surfactant and labrasol as an edge activator (EA). The impact of formulation factors on SNVs properties was investigated using a Box-Behnken design.
View Article and Find Full Text PDFMillions of acres of farmland in the midwestern United States (US) are artificially drained, and this contributes to the export of nitrogen (N) and phosphorus (P) from agricultural land to surface water. Using a 36-acre tile-drained farm field, effects of P-sorbing media in combination with a denitrifying bioreactor system constructed with woodchips (WC) and corn stover (CS) on reducing nutrient export in drainage water were tested for 3 cropping years (2018-2020). The field was divided into three subfields as replicates.
View Article and Find Full Text PDFPlants from the genus are gaining attention for their pharmacological importance. However, the information available regarding the HPLC-MS/MS chemical profile of is inadequate. In this study, we performed HPLC-MS/MS analysis using electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI).
View Article and Find Full Text PDFBackground: Cryptosporidiosis is a crucial zoonotic global health concern which can be treated by alternative medicinal plants extracts.
Aim Of The Study: The study was carried out to assess the therapeutic efficacy of Citrus sinensis peel ethanolic extract on Cryptosporidium-infected mice.
Methods: Two doses of Citrus sinensis extract; high dose (30 mg/kg) and low dose (15 mg/kg) were investigated compared to the common commercial drug nitazoxanide (NTZ).