Publications by authors named "E M Apfelbaum"
Ferroptosis emerged as a cell death modality for drug resistant cancer cells, but there are currently no available biomarkers for imaging ferroptosis based therapies. To address this gab, we evaluated the nanodynamic changes in lipid membranes occurring during cell death to explore potential targeting opportunities to image cell death. We nano-sized gaps at late stages of ferroptosis can serve as entry points for dyes that can bind to cellular structures.
View Article and Find Full Text PDFThis review examines diversity ideologies as influential tools for managing intergroup relations in organizations. Drawing from over two decades of scholarship, we consider our evolving understanding of what diversity ideologies are, how they manifest, and what consequences they have. Diversity ideologies are multi-level constructs that can be espoused or enacted.
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- Fluorescence-guided surgery relies on the ability of dyes to highlight tumor tissue compared to healthy tissue, and the dye CJ215 shows promise for this application due to its favorable optical properties.
- CJ215, a carbocyanine dye that is cleared by the kidneys, enables effective tumor detection and evaluation of wound healing within a day of intravenous injection, with minimal presence in healthy organs.
- In studies involving various cancer types, CJ215 provided significantly high contrast ratios for tumors compared to muscle and liver, and it also offered non-contact monitoring of wounds using shortwave infrared fluorescence imaging.
Article Synopsis
- Fluorescence guided surgery (FGS) uses special dyes for real-time identification of tumors, improving surgical outcomes by distinguishing tumors from healthy tissue.
- A specific dye, CJ215, targets apoptosis (cell death) and has been validated in various cancer models, showing high contrast imaging effectiveness in near infrared and shortwave infrared settings.
- CJ215 allows for detailed tumor visualization with minimal impact on healthy organs and can be used for tumor assessment, surgical guidance, and post-operative wound monitoring, integrating into current clinical practices.
Transparency about lagging diversity numbers signals genuine progress.
J Exp Psychol Gen
January 2024
Numerous organizations pledge to increase diversity, yet few publicly disclose how diverse they are. We suggest this reluctance to be transparent stems from an intuitive (albeit often misplaced) psychological calculation: that revealing struggles to increase diversity will undermine one's credibility and reputation. We evaluate the effects of transparency about lagging diversity numbers across four preregistered studies ( = 4,483), using real EEO-1 diversity disclosures from S&P 100 companies (Study 1) and information about the representation of racial/ethnic minorities in participants' own organizations (Studies 2-4).
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