Publications by authors named "E Lymberopoulos"
COVID-19 severity is associated with population-level gut microbiome variations.
Front Cell Infect Microbiol
September 2022
The human gut microbiome interacts with many diseases, with recent small studies suggesting a link with COVID-19 severity. Exploring this association at the population-level may provide novel insights and help to explain differences in COVID-19 severity between countries. We explore whether there is an association between the gut microbiome of people within different countries and the severity of COVID-19, measured as hospitalisation rate.
View Article and Find Full Text PDFThere is growing interest in the connection between the gut microbiome and human health and disease. Conventional approaches to analyse microbiome data typically entail dimensionality reduction and assume linearity of the observed relationships, however, the microbiome is a highly complex ecosystem marked by non-linear relationships. In this study, we use topological data analysis (TDA) to explore differences and similarities between the gut microbiome across several countries.
View Article and Find Full Text PDFArticle Synopsis
- The COVID-19 pandemic has caused major disruptions to clinical trials and research on the human gut microbiome, highlighting both direct and indirect effects on this area of study.
- Researchers note that COVID-19 may directly influence gut and lung microbiomes, while factors like lockdowns and changes in diet and hygiene can lead to long-term shifts in gut health.
- The pandemic poses challenges for clinical trials, especially those involving faecal microbiota transplants (FMT), affecting recruitment, sample sizes, and overall study design, necessitating urgent attention from researchers and funding bodies.
Social conformity is a class of social influence whereby exposure to the attitudes and beliefs of a group causes an individual to alter their own attitudes and beliefs towards those of the group. Compliance and acceptance are varieties of social influence distinguished on the basis of the attitude change brought about. Compliance involves public, but not private conformity, while acceptance occurs when group norms are internalised and conformity is demonstrated both in public and in private.
View Article and Find Full Text PDFIntroduction And Hypothesis: This pilot study compares protein expression patterns in the pubocervical fascia of women with pelvic organ prolapse (POP) and stress urinary incontinence (SUI) and asymptomatic women with normal pelvic support.
Methods: Samples of pubocervical fascia were collected from four women with POP and SUI and from three asymptomatic (control) women. These were analyzed using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.