Enamel hypoplasia in coeliac children: a potential clinical marker of early diagnosis.

Aim: To assess at the scansion electron microscope (SEM) the structural aspects of enamel hypoplasia (EH) in coeliac disease (CD) with the aim to investigate our hypothesis of a possible significant difference between structural characteristics of EH in CD affected patients and EH of non-coeliac patients. If the presence of specific features of the EH associated with CD were demonstrated, these findings would represent for the dentist early non-invasive clinical markers of diagnosis of CD in case of suspected disease.

Methods: We analysed at SEM two samples of enamel fragments from hypoplasic teeth, both deciduous and permanent, harvested from 10 coeliac children (18 permanent teeth, 6 deciduous teeth; study group) and 10 non-coeliac children (16 permanent teeth, 4 deciduous teeth; control group) treated for dental caries, dental extractions for extensive caries lesions or deciduous teeth exfoliation.

[Pharmacokinetics of 1-(4'-oxyphenyl)-2-(3'-phenyl-thiopropyl-amino) propane-1-01 hydrochloride (Istiod) in the rat].

The pharmacokinetics (serum, urinary and biliary concentrations) of Isotiod have been studied in rats. Doses exploited the property of the molecule in an alkaline medium with a diazonium salt to form coloured azo compounds. In rats Isotiod determines blood concentrations whose intensity and duration are proportional to the dose and route of administration; notable quantities of the drug are eliminated by the urinary way and a small quantity by the bile way with a personal technique.

[Experimental analysis of the immunizing and protective action of an association of total bacterial antigens].

The A. by a series of experimental works have shown that an association of total bacteria antigens (SPRE) administered in the rabbit vai intramuscular route or by inhalation is able to cause the appearance of serum specific antibodies and to have a significant protective action.