Publications by authors named "E Lopez-Bonet"

Fatty acid synthase (FASN)-catalyzed endogenous lipogenesis is a hallmark of cancer metabolism. However, whether FASN is an intrinsic mechanism of tumor cell defense against T cell immunity remains unexplored. To test this hypothesis, here we combined bioinformatic analysis of the FASN-related immune cell landscape, real-time assessment of cell-based immunotherapy efficacy in CRISPR/Cas9-based FASN gene knockout (FASN KO) cell models, and mathematical and mechanistic evaluation of FASN-driven immunoresistance.

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Background: ID3 (inhibitor of DNA binding/differentiation-3) is a transcription factor that enables metastasis by promoting stem cell-like properties in endothelial and tumor cells. The milk thistle flavonolignan silibinin is a phytochemical with anti-metastatic potential through largely unknown mechanisms.

Hypothesis/purpose: We have mechanistically investigated the ability of silibinin to inhibit the aberrant activation of ID3 in brain endothelium and non-small cell lung cancer (NSCLC) models.

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Article Synopsis
  • Women with Lynch syndrome (LS) have a higher risk of endometrial cancer (EC) due to issues like mismatch repair (MMR) deficiencies and microsatellite instability (MSI), prompting investigation into effective gynecologic surgery timing.
  • A study involving 93 LS women, 25 sporadic EC patients, and 30 benign disease controls assessed highly sensitive MSI (hs-MSI) in endometrial aspirates, revealing that hs-MSI was positively correlated with MMR-deficient cancer cases and loss of certain protein expressions.
  • The findings suggest that hs-MSI scores can help identify both premalignant and malignant conditions in LS carriers, potentially improving individualized surveillance strategies and surgical decision-making.
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Complete digital pathology transformation for primary histopathological diagnosis is a challenging yet rewarding endeavor. Its advantages are clear with more efficient workflows, but there are many technical and functional difficulties to be faced. The Catalan Health Institute (ICS) has started its DigiPatICS project, aiming to deploy digital pathology in an integrative, holistic, and comprehensive way within a network of 8 hospitals, over 168 pathologists, and over 1 million slides each year.

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