Publications by authors named "E Lopez de Santa Maria"
: This review aims to provide a comprehensive understanding of how HIV alters normal aging trajectories in the brain, presenting the HIV-related molecular mechanisms and pathophysiological pathways involved in brain aging. The review explores the roles of inflammation, oxidative stress, and viral persistence in the brain, highlighting how these factors contribute to neuronal damage and cognitive impairment and accelerate normal brain aging. Additionally, it also addresses the impact of antiretroviral therapy on brain aging and the biological markers associated with its occurrence.
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- The study highlights how underrepresentation in clinical genomics research diminishes the relevance of findings and benefits, particularly emphasizing the importance of diverse participant inclusion.
- Researchers implemented patient-centered, data-driven strategies, such as using relatable and flexible recruitment methods, to ensure a diverse sample of parents and children in a pediatric genome sequencing study.
- As a result, a high percentage of eligible participants agreed to enroll (93.5% acceptance) and the majority of those who enrolled completed the study, demonstrating the effectiveness of engaging with underrepresented communities.
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- The editorial discusses cardiac masses, which include a variety of lesions that can be neoplastic (tumors) or non-neoplastic, highlighting the rarity of primitive cardiac tumors compared to the more frequent metastases and pseudotumors.
- Effective diagnosis and treatment of cardiac masses present challenges, making multimodal imaging essential, with cardiac magnetic resonance (CMR) being the gold standard for non-invasive tissue characterization.
- While standard diagnostic flow charts are useful, the complex nature of cancer patients—especially those with rare conditions—requires a multidisciplinary approach and flexibility in thinking beyond traditional methods.
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- Inappropriate therapies (ITs) in patients with implantable cardioverter-defibrillators (ICDs) are often triggered by supraventricular tachyarrhythmias (SVTs).
- The THINGS study analyzed 526 patients with single-lead ICDs to estimate the IT incidence and identified factors like younger age and history of atrial fibrillation as significant risk contributors.
- Results showed a low IT rate of 4.2% at one year and 7.1% at two years, with dual-chamber (DC) discrimination showing a trend towards fewer ITs compared to single-chamber (SC) discrimination in the VT zone.
There is increasing evidence of the clinical utility of genetic and genomic testing (GT); however, factors influencing personal utility of GT, especially in diverse, multilingual populations, remain unclear. We explored these factors in a diverse cohort of parents/guardians (participants) whose children received clinical GT through the NYCKidSeq program. A total of 847 participants completed surveys at baseline, post-results disclosure, and 6 months (6m) post-results.
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