Publications by authors named "E Lombardini"
Developing techniques for the tagless isolation of homogeneous cell populations in physiological-like conditions is of great interest in medical research. A particular case is Gravitational Field-Flow Fractionation (GrFFF), which can be run avoiding cell fixation, and that was already used to separate viable cells. Cell dimensions have a key role in this process.
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- Virus-like particles (VLPs) are non-infectious subunit vaccines made from viral proteins that can effectively trigger immune responses, making them a promising option for various diseases, including COVID-19.
- In this study, researchers developed a chimeric VLP COVID-19 vaccine using proteins from both the influenza virus and the SARS-CoV-2 virus, showing that these engineered particles elicit strong antibody responses in mice.
- After vaccination, mice experienced significantly reduced viral loads and improved survival rates when exposed to SARS-CoV-2, demonstrating the vaccine's potential effectiveness and a balanced immune response while keeping inflammation and brain lesions under control.
remains one of the world's deadliest diseases and with ongoing concerns of evolving drug resistance, there is a need for continued refinement of the infection model in macaques to study severe malaria. As such, the systemic ultrastructural lesions associated with infection in splenectomized rhesus macaques was evaluated in 6 animals. Autopsy samples from multiple areas of the central nervous system (CNS), kidneys, heart, liver, and lungs of all 6 animals were processed for electron microscopy.
View Article and Find Full Text PDFPlasmodium coatneyi has been proposed as an animal model for human Plasmodium falciparum malaria as it appears to replicate many aspects of pathogenesis and clinical symptomology. As part of the ongoing evaluation of the rhesus macaque model of severe malaria, a detailed ultrastructural analysis of the interaction between the parasite and both the host erythrocytes and the microvasculature was undertaken. Tissue (brain, heart and kidney) from splenectomized rhesus macaques and blood from spleen-intact animals infected with P.
View Article and Find Full Text PDFIntroduction: At the start of the coronavirus disease 2019 (COVID-19) pandemic, Walter Reed Army Institute of Research (WRAIR) mobilized to rapidly conduct medical research to detect, prevent, and treat the disease in order to minimize the impact of the pandemic on the health and readiness of U.S. Forces.
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