Publications by authors named "E Liepins"
Article Synopsis
- The aspartic protease plasmepsin X (PMX) is crucial for the malaria parasite's lifecycle, making it a target for new antimalarial treatments.
- Researchers developed a series of macrocyclic compounds based on initial screening hits, significantly enhancing the potency and stability of these PMX inhibitors.
- One lead compound demonstrated strong effectiveness in inhibiting parasite growth and cleared infected mice's blood stage when given orally, indicating its potential as a viable antimalarial drug.
Our study aimed to evaluate the association between gastric cancer (GC) and higher concentrations of the metabolites L-carnitine, γ-butyrobetaine (GBB) and gut microbiota-mediated trimethylamine N-oxide (TMAO) in the circulation. There is evidence suggesting that higher levels of TMAO and its precursors in blood can be indicative of either a higher risk of malignancy or indeed its presence; however, GC has not been studied in this regard until now. Our study included 83 controls without high-risk stomach lesions and 105 GC cases.
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- Carbapenems are essential antibiotics but are losing effectiveness due to metallo-β-lactamases (MBLs), which are enzymes that break them down.
- Researchers discovered indole-2-carboxylates (InCs) as new inhibitors that can effectively target MBLs, maintaining activity against all major clinically relevant classes of these enzymes.
- In laboratory tests, InCs not only restored the effectiveness of carbapenems against drug-resistant Gram-negative bacteria but also demonstrated a good safety profile and strong efficacy when combined with the antibiotic meropenem in animal models of infection.
Evaluation of furanocoumarins from seeds of the wild parsnip (Pastinaca sativa L. s.l.).
J Chromatogr B Analyt Technol Biomed Life Sci
January 2019
Although the wild parsnip (Pastinaca sativa L. s.l.
View Article and Find Full Text PDFStable heterocyclic hydroperoxide can be easily prepared as a product of fast oxidation of a 1,2,3,4-tetrahydropyridine by (3)O2 if the solution is exposed to sunlight. The driving force for the photoinduced electron transfer is calculated from electrochemical and spectroscopic data. The outcome of the reaction depends on the light intensity and the concentration of O2.
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