Publications by authors named "E Lewallen"
Multipotent bone marrow mesenchymal stromal/stem cells (MSCs) respond to mechanical forces. MSCs perceive static and dynamic forces through focal adhesions, as well as cytoskeletal and intranuclear actin. Dynamic strain stimulates nuclear β-catenin (Ctnnb1) that controls gene expression and suppresses osteogenesis.
View Article and Find Full Text PDFRegenerative dental medicine continuously expands to improve treatments for prevalent clinical problems in dental and oral medicine. Stem cell based translational opportunities include regenerative therapies for tooth restoration, root canal therapy, and inflammatory processes (e.g.
View Article and Find Full Text PDFMany recent studies in evolutionary biology have expanded and refined definitions of biological evolution and natural selection. Current evolutionary models incorporate different adaptive and non-adaptive processes based on molecular genetic changes and how DNA is modified over time in unicellular species, or in germline versus somatic cells in metazoan species. Cogent arguments can be raised for the view that natural selection should be considered a biological law, consistent with quantitative mathematical equations that describe the fitness of individuals, as well as variations within and among populations.
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- Traumatic conditions during surgery can lead to early immune responses, potentially leading to long-lasting changes in leukocyte (white blood cell) activity and increased health risks.
- A study involving 13 patients undergoing elective cardiac surgery showed significant differences in gene expression in T cells and monocytes before and after surgery, indicating persistent changes in the immune system.
- Monocytes displayed specific gene expressions related to protein degradation and inflammation over time, suggesting ongoing issues that could affect recovery and health, emphasizing the need for careful clinical consideration post-surgery.
Article Synopsis
- - Bone development and maintenance are influenced by environmental factors and hormones that activate signaling pathways, affecting gene expression in the nucleus.
- - Gene expression related to bone is regulated by chromatin structure, which controls the accessibility of DNA sequences necessary for bone formation, especially during early embryonic stages to prevent premature mineralization.
- - Key epigenetic regulators, including various enzymes, play crucial roles in either promoting or inhibiting bone cell differentiation and function, impacting the behavior of stem cells and their development into bone-forming cells (osteoblasts).