Publications by authors named "E Lenze"
Importance: Depression and antidepressant use are independently associated with crash risk among older drivers. However, it is unclear what factors impact daily driving that increase safety risk for drivers with depression.
Objective: To examine differences in naturalistic driving behavior and safety between older adults with and without major depressive disorder (MDD).
Introduction: Oncologic surgeries are common and rates of depression and anxiety are high in the peri-operative period, potentially interfering with successful recovery.
Methods: We conducted a narrative review and meta-analysis focusing on randomised controlled trials evaluating the effect of peri-operative mental health interventions on anxiety and/or depression in adult patients having oncological surgery. The review included studies published in the last 5 years, identified through EMBASE with no pre-specified criteria for the type of comparison or outcome.
Article Synopsis
- The pandemic intensified awareness of depression's impact throughout life, prompting healthcare systems and advocates to prioritize prevention and treatment.
- Efforts continue to tackle the challenge of treating adult patients with difficult-to-treat depression who don’t respond to standard medications, while the psychiatric workforce faces limitations.
- The University of Arizona hosted the Southwest Forum on Difficult to Treat Depression in July 2024, bringing together experts to discuss innovative treatment methods, effective care algorithms, and improving access to depression care.
Introduction: Hip fractures may result from and contribute to accelerated biological aging. We aimed to evaluate the impact of hip fracture and its surgery on the senescence-associated secretory phenotype (SASP) index, a composite of peripheral protein markers where higher scores are thought to indicate greater levels of cellular senescence and accelerated aging.
Methods: We examined the SASP index in plasma over 12 weeks post-surgery and its prediction of long-term post-surgical functional outcomes.
Late-life depression (LLD) is often accompanied by medical comorbidities such as psychiatric disorders and cardiovascular diseases, posing challenges to antidepressant treatment. Recent studies highlighted significant associations between treatment-resistant depression (TRD) and polygenic risk score (PRS) for attention deficit hyperactivity disorder (ADHD) in adults as well as a negative association between antidepressant symptom improvement with both schizophrenia and bipolar. Here, we sought to validate these findings with symptom remission in LLD.
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