MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics.

Image-based spatial transcriptomics platforms are powerful tools often used to identify cell populations and describe gene expression in intact tissue. Spatial experiments return large, high-dimension datasets and several open-source software packages are available to facilitate analysis and visualization. Spatial results are typically imperfect.

The commitment of the human cell atlas to humanity.

The Human Cell Atlas (HCA) is a global partnership "to create comprehensive reference maps of all human cells-the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring, and treating disease." ( https://www.humancellatlas.

Distinctive physiology of molecularly identified medium spiny neurons in the macaque putamen.

The distinctive physiology of striatal medium spiny neurons (MSNs) underlies their ability to integrate sensory and motor input. In rodents, MSNs have a hyperpolarized resting potential and low input resistance. When activated, they have a delayed onset of spiking and regular spike rate.

TIBA: A web application for the visual analysis of temporal occurrences, interactions, and transitions of animal behavior.

Data in behavioral research is often quantified with event-logging software, generating large data sets containing detailed information about subjects, recipients, and the duration of behaviors. Exploring and analyzing such large data sets can be challenging without tools to visualize behavioral interactions between individuals or transitions between behavioral states, yet software that can adequately visualize complex behavioral data sets is rare. TIBA (The Interactive Behavior Analyzer) is a web application for behavioral data visualization, which provides a series of interactive visualizations, including the temporal occurrences of behavioral events, the number and direction of interactions between individuals, the behavioral transitions and their respective transitional frequencies, as well as the visual and algorithmic comparison of the latter across data sets.

Integrated multimodal cell atlas of Alzheimer's disease.

Alzheimer's disease (AD) is the leading cause of dementia in older adults. Although AD progression is characterized by stereotyped accumulation of proteinopathies, the affected cellular populations remain understudied. Here we use multiomics, spatial genomics and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying AD pathologies.