Publications by authors named "E Lee-Lewandrowski"
Evaluation of the rapid Quidel Sofia Lyme fluorescent immunoassay as a first-tier test in a modified 2-tier testing algorithm for Lyme disease: A comparison with the Zeus ELISA Borrelia VlsE1/pepC10 lgG/IgM assay followed by the Zeus monovalent IgM/IgG confirmatory assay.
Am J Clin Pathol
December 2023
Article Synopsis
- The recently approved modified 2-tier testing (MTTT) algorithms for Lyme disease now utilize two enzyme immunoassays (EIAs) instead of an EIA followed by an immunoblot.
- The Quidel Sofia Lyme fluorescent immunoassay, a rapid testing method, was evaluated as a first-tier test in comparison to the Zeus ELISA Borrelia test and confirmed with another EIA.
- Results showed the Sofia test had a 91.4% positive agreement and a 100% negative agreement with the standard MTTT, indicating it performs well as a Lyme disease screening method.
Article Synopsis
- Early detection of tumors in cancer patients leads to better treatment outcomes for less advanced cancers.
- Tumor-educated platelets (TEPs) can be used for cancer detection via RNA-based blood tests, identifying 18 different cancer types with high accuracy.
- The thromboSeq test showed 99% specificity in asymptomatic controls, accurately detecting two-thirds of cancers in advanced stages, and helped determine the origin of tumors in over 80% of cases.
Objectives: We evaluated trends in non-Lyme disease tick-borne disease (NLTBI) testing at a national reference laboratory.
Methods: Testing data performed at Quest Diagnostics during 2010 to 2016 were analyzed nationally and at the state level.
Results: Testing and positivity for most NLTBIs increased dramatically from 2010 through 2016 based on testing from a large reference laboratory.
Objectives: We evaluated trends in Lyme disease (LD) testing at a national reference laboratory.
Methods: LD screening enzyme immunoassay and Western blot testing data performed at Quest Diagnostics during 2010 to 2016 were analyzed nationally and at the state level.
Results: Overall, 593,800 (11.
Objectives: We evaluated changes in the testing menu, volume, and positivity rates for tick-borne illnesses in a New England medical center over an 11-year time frame.
Methods: Testing data were obtained by a retrospective review utilizing searchable data from a laboratory information system archive.
Results: Testing for tick-borne infections (TBI) increased 5.