Publications by authors named "E Leclerc"
Since its discovery in 1992, the receptor for advanced glycation end products (RAGE) has emerged as a key receptor in many pathological conditions, especially in inflammatory conditions. RAGE is expressed by most, if not all, immune cells and can be activated by many ligands. One characteristic of RAGE is that its ligands are structurally very diverse and belong to different classes of molecules, making RAGE a promiscuous receptor.
View Article and Find Full Text PDFMetabolic dysfunction-associated steatotic liver disease (MASLD; formerly known as NAFLD) is a common liver disease worldwide and carries the risk of progressing to severe liver conditions, such as fibrosis and liver cancer. In the context of MASLD, evaluating fat accumulation in the liver and the subsequent production of oxidative stress is essential to understand the disease propagation. However, clinical studies using human patients to investigate the fat accumulation and the onset of oxidative stress in MASLD face ethical and technical challenges, highlighting the importance of alternative methods.
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- Nonalcoholic fatty liver disease (NAFLD) can lead to severe liver issues and the study investigated how palmitic acid (PA), a common dietary fat, affects liver cells using organ-on-a-chip technology.
- After exposure to palmitic acid, the liver cells showed a decrease in liver transcription factor activity and expression changes in 318 genes, indicating early signs of liver cell dedifferentiation.
- Despite these changes, there was no lipid accumulation in the cells, but an increase in collagen production was observed, suggesting that palmitic acid contributes to the early stages of lipotoxicity associated with NAFLD.
Article Synopsis
- The study focuses on different subtypes of pancreatic β-cells that regulate insulin secretion and glucose balance, using 3D spheroids derived from human induced pluripotent stem cells (hiPSCs) to mimic these β-cell subtypes and islet-like structures.
- Researchers examined the signaling patterns of transcription regulators (TRs) in β-cell subpopulations through a systematic analysis of existing single-cell sequencing data, identifying key regulatory networks for these cells.
- The findings highlight the diversity among β-cell subtypes and propose mechanisms behind their differentiation, which could be crucial for understanding how imbalances in these subtypes contribute to insulin secretion issues in type 2 diabetes.
Type 2 diabetes (T2D) is posing a serious public health concern with a considerable impact on human life and health expenditures worldwide. The disease develops when insulin plasma level is insufficient for coping insulin resistance, caused by the decline of pancreatic β-cell function and mass. In β-cells, the lipotoxicity exerted by saturated free fatty acids in particular palmitate (PA), which is chronically elevated in T2D, plays a major role in β-cell dysfunction and mass.
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