Calcium hydroxylapatite tissue filler discovered 6 years after implantation into the nasolabial fold: case report and review.

Background: Injectable calcium hydroxylapatite is becoming increasingly popular as a facial soft tissue filler, due in part to its purported longevity of esthetic correction compared with other materials, but little is known about its long-term histologic appearance and persistence in facial skin. We recently encountered calcium hydroxylapatite microspheres incidentally during Mohs surgery of the nasolabial fold 6 years after implantation.

Objective: To describe the long-term histologic appearance of calcium hydroxylapatite microspheres in human facial skin and review the relevant literature with a consideration of clinical implications.

Generalized perforating granuloma annulare.

Generalized perforating granuloma annulare is characterized by 1 to 4 mm umbilicated papules on the extremities, and is most commonly seen in children and young adults. Transepithelial elimination of mucinous, degenerating collagen fibers and surrounding palisading lymphohistiocytic granulomas are important histologic features. Perforating sarcoidosis and perforating granuloma annulare may be difficult to differentiate because of a similar clinical appearance and the presence of sarcoidal granulomas in biopsy specimens.

Histology of proximal tubal obstruction in cases of unsuccessful tubal canalization.

Objective: To determine possible etiologies of unsuccessful fluoroscopically guided tubal canalization, we studied the histology of tubal segments in cases of failed canalization for proximal tubal obstruction. Factors contributing to cases of unsuccessful fluoroscopically guided tubal canalization remain unclear.

Design: Prospective.

Fine-needle aspiration biopsy of cold thyroid nodules.

This study analyzes the results of fine-needle aspiration biopsy (FNAB) of hypofunctioning thyroid nodules performed by one physician. There were 68 patients (age range, 20 to 73 years) with 83 aspirations; 30 were interpreted as positive for neoplasm (adenoma or carcinoma), 43 were negative, and ten (12%) were technically unsatisfactory. Thyroidectomy was performed on 25 patients who had positive aspirates.

Malignant fibrous histiocytoma of the pelvis.

A case of a 33-year-old Caucasian female with a malignant fibrous histiocytoma arising in the left ischiorectal fossa just under the left posterolateral vaginal wall is presented. Transvaginal simple excision of the tumor was followed by 5000 rad external beam whole pelvis irradiation and 6000 rad to the tumor bed. The patient is without evidence of disease 24 months after therapy and maintains normal vaginal function.