Publications by authors named "E Larocque"
Article Synopsis
- The demand for unconventional crude oils has led to increased production and transportation of diluted bitumen (dilbit) in Western Canada, but there's limited understanding of how spilled dilbit affects shallow groundwater systems.
- Experiments showed that dilbit spills result in higher concentrations and faster transport rates of harmful compounds (like BTEX and PACs) compared to spills of conventional heavy crude oil.
- Toxic effects were observed in fish larvae exposed to contaminated water, indicating that both oil types pose risks, potentially due to unknown toxic substances that can be transported in soil following spills.
Increasing global demands for oils are fueling the production of diluted bitumen (DB) from Canada's oil sands region. More weathered than conventional crude (CC) oils, Alberta bitumen is often diluted with lighter petroleum oils to reduce density and viscosity to meet pipeline specifications for transportation. Being a heavy oil product that is transported in large volumes across Canada and the USA, there has been interest to compare its behavior and toxicity characteristics when spilled to those of CC.
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- Activating mutations of FLT3 are linked to uncontrolled growth of hematopoietic stem and progenitor cells in acute myeloid leukemia (AML), contributing to poor patient survival.
- While treatments targeting mutant FLT3, like Quizartinib and Crenolanib, show promise, patients often develop resistance due to additional mutations and activated survival pathways.
- Two new FLT3 inhibitors, HSN608 and HSN748, effectively target resistant FLT3 mutations and demonstrate superior anti-leukemic activity compared to the existing FDA-approved drug Gilteritinib.
Human epidermal growth factor receptor 2 (HER2)-targeted agents have proven to be effective, however, the development of resistance to these agents has become an obstacle in treating HER2+ breast cancer. Evidence implicates HUNK as an anti-cancer target for primary and resistant HER2+ breast cancers. In this study, a selective inhibitor of HUNK is characterized alongside a phosphorylation event in a downstream substrate of HUNK as a marker for HUNK activity in HER2+ breast cancer.
View Article and Find Full Text PDFExercise addiction has sparked a growing interest in the scientific and clinical literature, yet this behavioral addiction has mainly been investigated quantitatively, from a positivistic perspective. This article explores the subjective and embodied dimensions of exercise addiction, broadening current conceptions of this emerging, still unofficial mental health category. Building on carnal sociology, and through a thematic analysis of mobile interviews conducted with 17 self-proclaimed "exercise addicts" from Canada, this article examines the interrelations between the embodiment of exercise addiction and the normative social elements at stake in the shaping of the category, providing insights on how exercise is experienced as an addiction.
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