Publications by authors named "E Lalle"
The impact of anti-Spike monoclonal antibody (mAbs) treatment on the immune response of COVID19-patients is poorly explored. In particular, a comparison of the immunological influence of different therapeutic regimens has not yet been performed. Aim of the study was to compare the kinetic of innate and adaptive immune response as well as the SARS-CoV-2 specific humoral and T cell response in two groups of SARS-CoV-2-infected patients treated with two different mAbs regimens: Bamlanivimab/Etesevimab (BAM/ETE) or Casirivimab/Imdevimab (CAS/IMD).
View Article and Find Full Text PDFThe recent outbreak of monkeypox virus (MPXV) has caused global concern. How the virus evades the interferon (IFN) response is still poorly understood. We analyzed type I/II IFN (IFN-I/II) expression in clinical samples from MPXV-infected patients and measured IFN-I kinetics in MPXV-infected cells.
View Article and Find Full Text PDFArticle Synopsis
- From August to November 2023, Italy reported 82 local cases of Dengue virus (DENV), with 10 cases specifically studied in Rome, showcasing a shift toward local transmission of the disease.
- The affected patients, mostly middle-aged and presenting classic dengue symptoms, were confirmed to have the virus through various laboratory tests including detection of DENV proteins and antibodies.
- The study emphasizes the importance of developing better surveillance and diagnosis strategies for DENV infections in non-endemic regions, to manage and understand the clinical progression of the disease.
Article Synopsis
- The 2022 global mpox outbreak was mainly spread through human-to-human transmission, but it's unclear how sexual relationships specifically contribute to this transmission.
- Researchers studied sexual transmission of mpox by analyzing clinical samples from 15 MPXV-positive patients in Italy, using a specific marker to indicate ongoing viral replication.
- Findings showed that the highest risk of infectivity came from skin lesions, and close or skin-to-skin contact during sex is the primary mode of transmission, with semen playing a much smaller role.