Intraosseous Delivery of Mesenchymal Stem Cells for the Treatment of Bone and Hematological Diseases.

Mesenchymal stem cells are used most in regenerative medicine due to their capacities in differentiation and immune modulation. The intraosseous injection of MSC into the bone has been recommended because of expected outcomes for retention, bioavailability, and enhanced therapeutic efficacy, particularly in conditions involving the bone, such as osteoporosis and osteonecrosis. A review of the intraosseous delivery of mesenchymal stem cells in comparison with intravenous and intra-arterial delivery methods will be subjected to critical examination.

[Intraosseous blockades and local injection of HYALREPAIR-02 Chondroreparant combination in low back pain treatment].

Objective: Studying the effectiveness of the combined use of intraosseous blockades (IOB) and intramuscular local injection therapy using bottled forms of HYALREPAIR-02 Chondroreparant 02/10 in patients with lumbar dorsopathy and recurrent back pain syndrome.

Material And Methods: 30 patients (16 men and 14 women) with chronic recurrent lumbar dorsopathy with pain and myofascial syndromes were examined. Group 1 included 17 patients, whose treatment included the use of IOB and intramuscular local injection therapy using bottled forms of HYALREPAIR-02 Chondroreparant 02/10.

[Results of a randomized double blind parallel study on the efficacy and safety of tolpersione in patients with acute nonspecific low back pain].

Aim: To evaluate the efficacy and safety of tolpersione injection and oral formulations combined with NSAID over NSAID monotherapy in acute non-specific low back pain.

Material And Methods: In this randomized double blind study 239 patients were included in the per protocol analysis. The first 5 days of treatment, patients received tolpersione or placebo injection which was followed by per os administration of tolpersione/placebo tablet up to 14 days.

[Low back pain and Modic changes].

Modic changes (MCh) are pathological changes in the bone marrow and the endplates of adjacent vertebrae characterized by bone marrow edema, fatty degeneration or osteosclerosis that are revealed by high-power field magnetic resonance imaging (MRI). The dominant disease pattern is a persistent back pain syndrome with varying intensity. It leads to difficulties in the interpretation of clinical data, evaluation of MRI data and treatment.

[Intraosseous blocks in the treatment of symmetrical distal diabetic polyneuropathy].

Aim: To evaluate the efficiency of intraosseous blocks (IOB) in the combination treatment of patients with painful diabetic symmetrical distal polyneuropathy (DSDP) of the lower limbs.

Subjects And Methods: Seventy-eight patients with painful DSDP were examined. Its diagnosis was verified by neurological examination, assessments of the data of the neuropathic pain diagnostic (DN4) questionnaire and electroneuromyography (ENMG).