[Aspects of the use of medical devices for remote patient monitoring].

In the Russian Federation, it is legally determined that telemedicine technologies are considered as any actions with any data obtained during a remote communication between doctors (councils, consultations), remote medical patient monitoring, including using medical devices. Medical devices with a function of remote transmission of the measurement data are used to detect diseases in some workers that impede their duty performance. There are hardly any publications on the experience of using such devices in other aspects of medical care.

Tryptophan Hydroxylase-2-Mediated Serotonin Biosynthesis Suppresses Cell Reprogramming into Pluripotent State.

The monoamine neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has important functions both in the neural system and during embryonic development in mammals. In this study, we set out to investigate whether and how endogenous serotonin affects reprogramming to pluripotency. As serotonin is synthesized from tryptophan by the rate limiting enzymes tryptophan hydroxylase-1 and -2 (TPH1 and TPH2), we have assessed the reprogramming of TPH1- and/or TPH2-deficient mouse embryonic fibroblasts (MEFs) to induced pluripotent stem cells (iPSCs).

Dual Mode of Mitochondrial ROS Action during Reprogramming to Pluripotency.

Essential changes in cell metabolism and redox signaling occur during the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs). In this paper, using genetic and pharmacological approaches, we have investigated the role of electron transport chain (ETC) complex-I (CI) of mitochondria in the process of cell reprogramming to pluripotency. Knockdown of NADH-ubiquinone oxidoreductase core subunits S1 (Ndufs1) or subunit B10 (Ndufb10) of the CI or inhibition of this complex with rotenone during mouse embryonic fibroblast (MEF) reprogramming resulted in a significantly decreased number of induced pluripotent stem cells (iPSCs).

HDAC Inhibitor Sodium Butyrate Attenuates the DNA Repair in Transformed but Not in Normal Fibroblasts.

Many cancer therapy strategies cause DNA damage leading to the death of tumor cells. The DNA damage response (DDR) modulators are considered as promising candidates for use in combination therapy to enhance the efficacy of DNA-damage-mediated cancer treatment. The inhibitors of histone deacetylases (HDACis) exhibit selective antiproliferative effects against transformed and tumor cells and could enhance tumor cell sensitivity to genotoxic agents, which is partly attributed to their ability to interfere with DDR.

[The adolescents, Internet and drug abuse].

According to results of research study, in 2016-2017, the number of Internet users among schoolchildren was 96% of boys and 97% of girls and at that 44% of boys and 60% of girls spend 3 hours or more on the Internet daily. Quite often excessive infatuation for Internet is combined with psychoactive substances abuse. The purpose of the study is to identify features of abuse of drug and other toxicomanic substances among adolescents who used the Internet continuously on daily basis.