Publications by authors named "E L Sciuto"
Article Synopsis
- Pouchitis is an inflammatory disease that can affect ileal pouches, potentially leading to pouch failure, and this study looks into the effects of a specific probiotic strain, DG®, on this condition.
- In a randomized trial with 52 patients post-restorative proctocolectomy, participants received either DG® or a placebo for 8 weeks, during which researchers monitored inflammatory cytokine levels in the pouch mucosa at multiple points.
- Results showed that the group receiving DG® had significantly reduced levels of inflammatory cytokines after 8 weeks compared to their baseline, indicating the probiotic may positively influence the pouch microenvironment.
The pandemic outbreak caused by SARS-CoV-2 coronavirus brought a crucial issue in public health causing up to now more than 600 million infected people and 6.5 million deaths. Conventional diagnostic methods are based on quantitative reverse transcription polymerase chain reaction (RT-qPCR assay) and immuno-detection (ELISA assay).
View Article and Find Full Text PDF55 million people worldwide suffer from Alzheimer's disease (AD). A definitive diagnosis of AD is made postmortem after a neuropathological examination of the brain. There is an urgent need for an innovative, noninvasive methodology that allows for an early and reliable diagnosis.
View Article and Find Full Text PDFLarge bone defect treatments have always been one of the important challenges in clinical practice and created a huge demand for more efficacious regenerative approaches. The bone tissue engineering (BTE) approach offered a new alternative to conventional bone grafts, addressing all clinical needs. Over the past years, BTE research is focused on the study and realisation of new biomaterials, including 3D-printed supports to improve mechanical, structural and biological properties.
View Article and Find Full Text PDFThe recent SARS-CoV-2 pandemic has highlighted the urgent need for novel point-of-care devices to be promptly used for a rapid and reliable large screening analysis of several biomarkers like genetic sequences and antibodies. Currently, one of the main limitations of rapid tests is the high percentage of false negatives in the presence of variants and, in particular for the Omicron one. We demonstrate in this work the detection of SARS-CoV-2 and the Omicron variant with a cost-effective silicon nanosensor enabling high sensitivity, selectivity, and fast response.
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