Publications by authors named "E L Rapaport"

Article Synopsis
  • Elevated ATP levels in cystic fibrosis (CF) patients may provide health benefits, particularly in fighting advanced solid tumors.
  • Research indicates that intravenous ATP can restore ATP levels in cancer patients, leading to improvements in their health and quality of life.
  • The authors propose that the high ATP levels in CF patients could also enhance their survival rates after contracting COVID-19, and they explore the potential clinical applications of this hypothesis.
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In 2018, NHS England released guidelines restricting the prescription of over-the-counter medicines (OTC). This was a project initially targeted at primary care, but we felt that it could also be used to improve services in secondary or tertiary care. We were interested to investigate our OTC prescribing pattern within a busy maxillofacial department and therefore carried out a service review.

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Article Synopsis
  • The study explored if higher-intensity exercise leads to greater reductions in inflammation markers in people with HIV (PWH) compared to controls.
  • Participants aged 50-75 completed 12 weeks of moderate-intensity exercise followed by 12 weeks of randomized moderate- or high-intensity workouts, with inflammatory markers measured at various intervals.
  • Results indicated no significant differences in inflammation changes based on HIV status or exercise intensity; however, high-intensity exercisers showed some notable increases in specific markers that warrant further investigation.
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Cytomegalovirus (CMV) is associated with poor outcomes, including physical function impairment, in older HIV-uninfected adults. Whether CMV is associated with physical functional impairment in HIV-infected adults is unknown. The primary objective of this study was to determine the relationship between CMV-specific humoral and cell-mediated immune responses with functional impairment in well-controlled HIV infection.

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Sclerostin is linked to bone physiology and cardiovascular disease through the Wnt/β-catenin signaling pathway. The goal of this study was to determine if sclerostin is related to bone physiology and cardiovascular disease during antiretroviral treatment in HIV-infected persons. This was a cross-sectional analysis from study entry into the Stopping Atherosclerosis and Treating Unhealthy bone with RosuvastatiN in HIV (SATURN) trial, an ongoing randomized trial comparing rosuvastatin to placebo in HIV-infected adults on antiretroviral therapy.

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