Copper(II) Chelates of Schiff Bases Enriched with Aliphatic Fragments: Synthesis, Crystal Structure, In Silico Studies of ADMET Properties and a Potency against a Series of SARS-CoV-2 Proteins.

We report two complexes [Cu(L)] () and [Cu(L)] () (HL = -cyclohexyl-3-methoxysalicylideneimine, HL = -cyclohexyl-3-ethoxysalicylideneimine). The ligands in both complexes are -1,5-N,O-coordinated, yielding a square planar CuNO coordination core. The molecule of is planar with two cyclohexyl groups oriented to the opposite sites of the planar part of a molecule, while the molecule of is significantly bent with two cyclohexyl groups oriented to the same convex site of a molecule.

Single-domain antibody delivery using an mRNA platform protects against lethal doses of botulinum neurotoxin A.

Single-domain antibodies (sdAbs, VHHs, or nanobodies) are a promising tool for the treatment of both infectious and somatic diseases. Their small size greatly simplifies any genetic engineering manipulations. Such antibodies have the ability to bind hard-to-reach antigenic epitopes through long parts of the variable chains, the third complementarity-determining regions (CDR3s).

ML-Based Analysis of Particle Distributions in High-Intensity Laser Experiments: Role of Binning Strategy.

When entering the phase of big data processing and statistical inferences in experimental physics, the efficient use of machine learning methods may require optimal data preprocessing methods and, in particular, optimal balance between details and noise. In experimental studies of strong-field quantum electrodynamics with intense lasers, this balance concerns data binning for the observed distributions of particles and photons. Here we analyze the aspect of binning with respect to different machine learning methods (Support Vector Machine (SVM), Gradient Boosting Trees (GBT), Fully-Connected Neural Network (FCNN), Convolutional Neural Network (CNN)) using numerical simulations that mimic expected properties of upcoming experiments.

Western European influence on the development of Russian neurology and psychiatry, part 1: Western European tours of early Russian neurologists and psychiatrists.

Beginning in the 1860s, two major centers of neurology and psychiatry arose in Russia: Imperial Moscow University (IMU) and Imperial Medical and Surgical Academy in St. Petersburg (IMSA). Both centers were strongly influenced by Leading Western European schools and specialists, through the clinical and research training regimes of both Russian universities, strongly influenced these centers of learning.